Registration Dossier

Administrative data

Description of key information

Acute oral toxicity: LD₅₀ > 5000 mg/kg bw, similar to OECD Guideline 423 (Dow Corning Corporation, 1980c).

Acute dermal toxicity: LD₅₀ > 2000 mg/kg bw, similar to OECD Guideline 402 (Dow Corning Corporation, 1980d).

Key value for chemical safety assessment

Acute toxicity: via oral route

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed
Dose descriptor:
LD50
Value:
5 000 mg/kg bw

Acute toxicity: via inhalation route

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed

Acute toxicity: via dermal route

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed
Dose descriptor:
LD50
Value:
2 000 mg/kg bw

Additional information

Oral

Reaction Mass of bis(trimethoxysilylpropyl)methylphosphonate and (trimethoxysilylpropyl)methylmethylphosphonate has been tested in an acute oral toxicity study conducted according to a guideline equivalent to OECD TG 401. The undiluted test substance was administered by gavage to 5 male and 5 female rats at 5000 mg/kg. All rats exhibited weakness and drowsiness for several hours after the treatment. One female rat died after one hour but the remaining animals appeared normal at 48 hours after treatment, and all remaining animals survived the 14 day observation period. Under the test conditions, the test substance has a very low acute oral toxicity. The LD50 was determined to be greater than 5000 mg/kg bw (Dow Corning Corporation 1980c).

Dermal

In an acute dermal toxicity study Reaction Mass of bis(trimethoxysilylpropyl)methylphosphonate and (trimethoxysilylpropyl)methylmethylphosphonate was tested in a limit test conducted according to a test guideline equivalent to OECD TG 402. Single dermal administration at 2000 mg/kg to five male and five female rabbits did not result in mortality. The acute dermal LD50 was therefore established to be greater than 2000 mg/kg in this study (Dow Corning Corporation 1980d).


Justification for classification or non-classification

Based on the available information for Reaction Mass of bis(trimethoxysilylpropyl)methylphosphonate and (trimethoxysilylpropyl)methylmethylphosphonate, the substance does not require classification for acute toxicity according to Regulation (EC) No 1272/2008.