4''-Ethyl-2',3,4,5-tetrafluor-1,1':4',1''-terphenyl

Water solubility

Link to relevant study record(s)

Reference

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

key study

Study period:

19.-25.06.2015

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

EU Method A.6 (Water Solubility)

Version / remarks:

European Commission Regulation (EC) No. 440/2008

Deviations:

no

Qualifier:

according to guideline

Guideline:

OECD Guideline 105 (Water Solubility)

Deviations:

no

GLP compliance:

no

Type of method:

column elution method

Key result

Water solubility:

< 0.044 mg/L

Conc. based on:

test mat.

Temp.:

20 °C

pH:

> 5.6 - < 5.7

Preliminary Visual Estimation of the Water Solubility

 

The solubility of the test item in water was found to be below 8.6 mg/L (without correction for the purity). According to the guideline the column elution method is the appropriate method for solubilities below 10 mg/L therefore this method was used for the main test.

Appearance of the test mixtures

Amount of the test item in mg	Total volume in mL	Appearance of mixture
17.1	100	undissolved
12.0	500	undissolved
4.3	500	undissolved

 

Concentration and pH

 

Column 1

Fraction no.	V in mL	pH	water solubility in µg/L
21	18.0	5.6	< 44
22	18.0	5.7	< 44
23	18.0	5.7	< 44
24	18.0	5.7	< 44
25	18.0	5.7	< 44

The water solubility was found to be below the quantification limit of 44 μg/L.

 

Column 2

Fraction no.	V in mL	pH	water solubility in µg/L
49	18.5	5.7	< 44
50	18.5	5.7	< 44
51	18.5	5.7	< 44
52	18.5	5.7	< 44
53	18.5	5.7	< 44

 The water solubility was found to be below the quantification limit of 44 μg/L.

 

Coating check: The coating check was successful. Enough residual test item remained an the columns.

Conclusions:

The water solubility at a temperature of 20 °C was determined to be below the quantification limit: < 0.044 mg/L. 

Executive summary:

The water solubility was determined according to OECD 105 using the column elution method with HPLC analysis . Therefore, two identical columns were prepared; one of them was exposed to a flow rate of about 12.5 mL/h (column 1), the other one to 25.0 mL/h (column 2). The concentration of test item was determined by means of HPLC. The volumes of all fractions were measured. For the analysed fractions the pH values and the temperatures were measured, too. For column 1 the fractions 21 to 25 were evaluated. The water solubility was found to be smaller than 0.044 mg/L. For column 2 the fractions 49 to 53 were evaluated. The water solubility was found to be smaller than 0.044 mg/L. The water solubility at a temperature of 20 °C was determined to be below the quantification limit: < 0.044 mg/L. 

Description of key information

The water solubility at a temperature of 20 °C was determined to be below the quantification limit: < 0.044 mg/L. 

Additional information

The water solubility was determined according to OECD 105 using the column elution method with HPLC analysis. Therefore, two identical columns were prepared; one of them was exposed to a flow rate of about 12.5 mL/h (column 1), the other one to 25.0 mL/h (column 2). The concentration of test item was determined by means of HPLC. The volumes of all fractions were measured. For the analysed fractions the pH values and the temperatures were measured, too. For column 1 the fractions 21 to 25 were evaluated. The water solubility was found to be smaller than 0.044 mg/L. For column 2 the fractions 49 to 53 were evaluated. The water solubility was found to be smaller than 0.044 mg/L. The water solubility at a temperature of 20 °C was determined to be below the quantification limit: < 0.044 mg/L.