Registration Dossier
Registration Dossier
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EC number: 943-705-7 | CAS number: 947686-05-7
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vitro
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 019
- Report date:
- 2019
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 442D (In Vitro Skin Sensitisation: ARE-Nrf2 Luciferase Test Method)
- GLP compliance:
- yes (incl. QA statement)
- Type of study:
- activation of keratinocytes
Test material
- Reference substance name:
- 3',5-bis(prop-2-en-1-yl)-[1,1'-biphenyl]-2,4'-diol; 5,5'-bis(prop-2-en-1-yl)-[1,1'-biphenyl]-2,2'-diol
- Cas Number:
- 947686-05-7
- Molecular formula:
- C18H18O2
- IUPAC Name:
- 3',5-bis(prop-2-en-1-yl)-[1,1'-biphenyl]-2,4'-diol; 5,5'-bis(prop-2-en-1-yl)-[1,1'-biphenyl]-2,2'-diol
- Test material form:
- solid
Constituent 1
Results and discussion
In vitro / in chemico
Results
- Key result
- Run / experiment:
- other: This in vitro study was performed to investigate the potential of Magnolia Officinalis Bark Extract to activate the Nrf2 transcription factor, by using the LuSens cell line.
- Parameter:
- other: activation of Nrf2 transcription factor
- Value:
- 1.5
- Vehicle controls validity:
- valid
- Negative controls validity:
- valid
- Positive controls validity:
- valid
Applicant's summary and conclusion
- Interpretation of results:
- Category 1B (indication of skin sensitising potential) based on GHS criteria
- Conclusions:
- Under the experimental conditions of this study, the test item, Magnolia Officinalis Bark Extract, was positive in the LuSens assay and is therefore considered to have the potential to activate the Nrf2 transcription factor.
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