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Toxicological information

Skin sensitisation

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Administrative data

Endpoint:
skin sensitisation: in vitro
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2019
Report date:
2019

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 442D (In Vitro Skin Sensitisation: ARE-Nrf2 Luciferase Test Method)
GLP compliance:
yes (incl. QA statement)
Type of study:
activation of keratinocytes

Test material

Constituent 1
Chemical structure
Reference substance name:
3',5-bis(prop-2-en-1-yl)-[1,1'-biphenyl]-2,4'-diol; 5,5'-bis(prop-2-en-1-yl)-[1,1'-biphenyl]-2,2'-diol
Cas Number:
947686-05-7
Molecular formula:
C18H18O2
IUPAC Name:
3',5-bis(prop-2-en-1-yl)-[1,1'-biphenyl]-2,4'-diol; 5,5'-bis(prop-2-en-1-yl)-[1,1'-biphenyl]-2,2'-diol
Test material form:
solid

Results and discussion

In vitro / in chemico

Results
Key result
Run / experiment:
other: This in vitro study was performed to investigate the potential of Magnolia Officinalis Bark Extract to activate the Nrf2 transcription factor, by using the LuSens cell line.
Parameter:
other: activation of Nrf2 transcription factor
Value:
1.5
Vehicle controls validity:
valid
Negative controls validity:
valid
Positive controls validity:
valid

Applicant's summary and conclusion

Interpretation of results:
Category 1B (indication of skin sensitising potential) based on GHS criteria
Conclusions:
Under the experimental conditions of this study, the test item, Magnolia Officinalis Bark Extract, was positive in the LuSens assay and is therefore considered to have the potential to activate the Nrf2 transcription factor.