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Physical & Chemical properties

Partition coefficient

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partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
From 04 FEBRUARY 2019 to 27 FEBRUARY 2019
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
according to guideline
OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
GLP compliance:
yes (incl. QA statement)
Type of method:
HPLC method
Partition coefficient type:
Analytical method:
high-performance liquid chromatography
Key result
log Pow
Partition coefficient:
ca. 5.2
25 °C
> 4 - < 5
Details on results:
5.2 ± 0.0
The log POW of the test item 1-butyl-5-[(4-chlorophenyl)azo]-1,2-dihydro-6-hydroxy-4-
methyl-2-oxonicotinonitrile was calculated as 5.2 ± 0.0 (mean ± standard deviation).

Description of key information

According to OECD 117 resp. EU A.24

Key value for chemical safety assessment

Log Kow (Log Pow):
at the temperature of:
25 °C

Additional information

Variations in the retention times of reference items and test item were very small, demonstrating a stable configuration of the HPLC system.
The correlation log k / log P
OW is good: the coefficient of determination r2 was calculated with 0.9943. This value was considered as sufficiently high to use the calibration function for the determination of the log POW of the test item 1-butyl-5-[(4-chlorophenyl)azo]-1,2-dihydro-6-hydroxy-4-methyl-2-oxonicotinonitrile.
The log P
OW of the test item 1-butyl-5-[(4-chlorophenyl)azo]-1,2-dihydro-6-hydroxy-4-methyl-2-oxonicotinonitrile was calculated as 5.2 ± 0.0 (mean ± standard deviation).
No observations were made which might cause doubts concerning the validity of the study outcome.