Benzododecinium chloride

Solubility in organic solvents / fat solubility

Link to relevant study record(s)

Reference

Endpoint:

solubility in organic solvents / fat solubility

Type of information:

experimental study

Adequacy of study:

key study

Study period:

From June 27, 2019 to July 09, 2019

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

comparable to guideline study

Qualifier:

equivalent or similar to guideline

Guideline:

other: Preliminary solubility test as per OECD Guideline 107

GLP compliance:

yes (incl. QA statement)

Key result

Medium:

n-octanol

Solubility:

ca. 584 - ca. 866 g/L

Temp.:

24 °C

Results

The preliminary test at room temperature showed that the 1-octanol solubility of the test substance was in range of 584 to 866 g/L.

Total amount of added test substance (g)	Volume of 1-octanol (mL)	Stirring time at room temperature (min)	Remark
0.62	5	45	dissolved
1.51		45	dissolved
2.28		50	dissolved
2.92		75	dissolved
4.33		915	not dissolved

Conclusions:

Under the study conditions, n-octanol solubility of the test substance was determined to be 584 to 866 g/L at 24°C.

Executive summary:

A study was conducted to determine the n-octanol solubility of the substance, using preliminary solubility test method according to the OECD Guideline 107, in compliance with GLP. Under the study conditions, n-octanol solubility of the test substance was determined to be 584 to 866 g/L at 24°C (Hartmann, 2019)

Description of key information

The n-octanol solubility of the test substance was determined using the preliminary solubility test method as part of the partition coefficient test according to the OECD Guideline 107 (Hartmann, 2019).

Key value for chemical safety assessment

At the temperature of:

24 °C

Solubility in organic solvents at 20°C:

866 g/L

Additional information

n-octanol solubility of test substance range: 584 to 866 g/L at 24°C