Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 951-766-6 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1973
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Basic data given, but considered sufficiently reliable for the purpose of hazard assessment.
Cross-referenceopen allclose all
- Reason / purpose for cross-reference:
- reference to same study
Reference
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1973
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Documentation insufficient for assessment
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to other study
- Principles of method if other than guideline:
- Method according to the typical testing for acute dermal toxicity test: topical application of substance on rabbits at several doses.
- GLP compliance:
- no
- Remarks:
- (pre-GLP)
- Species:
- rabbit
- Strain:
- not specified
- Details on test animals or test system and environmental conditions:
- No data
- Type of coverage:
- not specified
- Preparation of test site:
- not specified
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 320, 1250, 2500 and 5000 mg/kg bw - Duration of treatment / exposure:
- Single treatment (24 h exposure)
- Observation period:
- 14 days
- Number of animals:
- 2 animals at 320 mg/kg bw
4 animals at 1250 mg/kg bw
4 animals at 2500 mg/kg bw
2 animals at 5000 mg/kg bw - Details on study design:
- No data
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- 24 h
- Remarks on result:
- probability of moderate irritation
- Irritation parameter:
- erythema score
- Basis:
- animal #2
- Time point:
- 24 h
- Remarks on result:
- probability of moderate irritation
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Time point:
- 24 h
- Remarks on result:
- probability of weak irritation
- Irritation parameter:
- edema score
- Basis:
- animal #2
- Time point:
- 24 h
- Remarks on result:
- probability of moderate irritation
- Irritant / corrosive response data:
- Mortality:
- At 320 mg/kg bw: 0/2
- At 1250 mg/kg bw: 3/4
- At 2500 mg/kg bw: 2/4
- At 5000 mg/kg bw: 2/2
- Dermal reactions: moderate redness in 2, slight redness in 3. - Other effects:
- Clinical signs: none at 320 mg/kg bw. Anorexia and diarrhea observed at all higher doses.
- Interpretation of results:
- study cannot be used for classification
- Conclusions:
- Under the test conditions, the test substance induced slight to moderate skin irritation in rabbits.
- Executive summary:
In an acute dermal toxicity study, Tonka Absolute wasgiven by dermal application at a dose level of 320, 1250, 2500 and 5000 mg/kg bw in rabbits. Animals were observed for mortality and clinical signs for 14 days.
Mortality occurred during the study (3/4 at 1250 mg/kg bw, 2/4 at 2500 mg/kg bw and 2/4 at 5000 mg/kg bw). Anorexia and diarrhea were observed at all higher doses, slight redness in three rabbits and moderate in two others. In this study, the dermal LD50 of Tonka Absolute was 1260 mg/kg bw in rabbits.
Under the test conditions, the test substance induced slight to moderate skin irritation in rabbits.
This study was conducted according to a non-standard method and adequate scoring of skin effects was not provided, therefore it was not possible to take a decision on the classification based solely on this study.
Acute dermal LD50 of test material is 1380 mg/kg bw
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 973
- Report date:
- 1973
Materials and methods
- Principles of method if other than guideline:
- - Standard acute method (limit test)
- GLP compliance:
- no
- Remarks:
- (pre GLP)
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Absolute of Dipteryx odorata (Fabaceae) obtained from beans by organic solvents treatment and subsequent ethanol extraction
- EC Number:
- 951-766-6
- Molecular formula:
- Not relevant, UVCB substance
- IUPAC Name:
- Absolute of Dipteryx odorata (Fabaceae) obtained from beans by organic solvents treatment and subsequent ethanol extraction
- Test material form:
- other: Crystal
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- No data.
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- No data.
- Duration of exposure:
- 24 h
- Doses:
- 320, 1250, 2500 and 5000 mg/kg bw
- No. of animals per sex per dose:
- 2 animals at 320 mg/kg bw
4 animals at 1250 mg/kg bw
4 animals at 2500 mg/kg bw
2 animals at 5000 mg/kg bw - Control animals:
- not required
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations: Clinical observations, observations for mortality and toxic effects were made daily for 14 days
- Necropsy of survivors performed: No data - Statistics:
- None
Results and discussion
- Preliminary study:
- Not applicable
Effect levels
- Key result
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- ca. 1 260 mg/kg bw
- Based on:
- test mat.
- Mortality:
- - At 320 mg/kg bw: 0/2
- At 1250 mg/kg bw: 3/4
- At 2500 mg/kg bw: 2/4
- At 5000 mg/kg bw: 2/2 - Clinical signs:
- other: - Clinical signs: none at 320 mg/kg bw. Anorexia and diarrhea observed at all higher doses. - Dermal reactions: moderate redness in 2, slight redness in 3.
- Gross pathology:
- No data available.
- Other findings:
- No data.
Any other information on results incl. tables
None
Applicant's summary and conclusion
- Interpretation of results:
- Category 4 based on GHS criteria
- Conclusions:
- Under the test conditions, the dermal LD50 for test substance is 1260 mg/kg bw in rabbits. Therefore the test substance is classified as harmful in contact with skin according to the criteria of the Annex I of the Regulation (EC) No. 1272/2008 (CLP) and to the GHS.
- Executive summary:
In an acute dermal toxicity study, Tonka Absolute was given by dermal application at a dose level of 320, 1250, 2500 and 5000 mg/kg bw in rabbits. Animals were observed for mortality and clinical signs for 14 days.
Mortality occurred during the study (3/4 at 1250 mg/kg bw, 2/4 at 2500 mg/kg bw and 2/4 at 5000 mg/kg bw). Anorexia and diarrhea were observed at all higher doses, slight redness in three rabbits and moderate in two others. In this study, the dermal LD50 of Tonka Absolute was 1260 mg/kg bw in rabbits.
Under the test conditions, the dermal LD50 for test substance is 1260 mg/kg bw in rabbits. Therefore the test substance is classified as harmful in contact with skin according to the criteria of the Annex I of the Regulation (EC) No. 1272/2008 (CLP) and to the GHS.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.