Registration Dossier
Registration Dossier
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EC number: 234-207-4 | CAS number: 10595-80-9
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1957
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 957
- Report date:
- 1957
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Groups of 2 rats per dose were orally dosed with an aqueous suspension of the test material.
- GLP compliance:
- no
- Remarks:
- GLP regulations were not in place at the time of the study
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Sulphoethyl methacrylate
- EC Number:
- 234-207-4
- EC Name:
- Sulphoethyl methacrylate
- Cas Number:
- 10595-80-9
- Molecular formula:
- C6H10O5S
- IUPAC Name:
- sulphoethyl methacrylate
- Test material form:
- liquid: viscous
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- not specified
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- water
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 20%
- Amount of vehicle (if gavage): not specified - Doses:
- 2000, 3980 mg/kg bw
- No. of animals per sex per dose:
- 2
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: not specified
- Frequency of observations and weighing: not specified
- Necropsy of survivors performed: no
- Other examinations performed: not specified
Results and discussion
Effect levelsopen allclose all
- Key result
- Sex:
- not specified
- Dose descriptor:
- LD0
- Effect level:
- 2 000 mg/kg bw
- Based on:
- test mat.
- Key result
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- ca. 3 980 mg/kg bw
- Based on:
- test mat.
- Mortality:
- no animal died at 2000 mg/kg bw
1 out of 2 animals died at 3980 mg/kg bw, 14 d after dosing - Clinical signs:
- other: not specified
- Gross pathology:
- not specified
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- 2-SEM is not classified for acute toxicity since no mortality occurred after dosing with 2000 mg/kg bw
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