Registration Dossier

Administrative data

Description of key information

The capacity of Phenol, ethoxylated to induce skin sensitisation was assessed based on the available information on its constituents.

2-phenoxyethanol and 2-(2-phenoxyethoxy)ethanol are not classified as sensitising to the skin based on available experimental data.

Considering the structural similarities between the constituents of Phenol, ethoxylated and in the absence of experimental data on the substance, 2-[2-(2-phenoxyethoxy)ethoxy]ethanol is not expected to induce skin sensitisation.

It is concluded that Phenol, ethoxylated does not meet the criteria for classification as sensitising to the skin according to the CLP Regulation.

Key value for chemical safety assessment

Skin sensitisation

Link to relevant study records
Reference
Endpoint:
skin sensitisation: in vitro
Type of information:
other: expert assessment
Adequacy of study:
key study
Study period:
2019
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Assessment based on the properties of the indvidiual constituents of the substance
Qualifier:
no guideline required
Principles of method if other than guideline:
An assessment was conducted based on the properties of the indvidiual constituents of the substance.
GLP compliance:
no
Type of study:
other: Assessment based on the properties of the indvidiual constituents of the substance
Remarks on result:
other: An assessment was conducted based on the properties of the indvidiual constituents of the substance. It concluded that Phenol, ethoxylated does not meet the criteria for classification as sensitising to the skin according to the CLP Regulation.
Interpretation of results:
GHS criteria not met
Conclusions:
An assessment was conducted based on the properties of the indvidiual constituents of the substance. It concluded that Phenol, ethoxylated does not meet the criteria for classification as sensitising to the skin according to the CLP Regulation.
Executive summary:

The capacity of Phenol, ethoxylated to induce skin sensitisation was assessed based on the available information on its constituents.

2-phenoxyethanol and 2-(2-phenoxyethoxy)ethanol are not classified as sensitising to the skin based on available experimental data.

Considering the structural similarities between the constituents of Phenol, ethoxylated and in the absence of experimental data on the substance, 2-[2-(2-phenoxyethoxy)ethoxy]ethanol is not expected to induce skin sensitisation.

It is concluded that Phenol, ethoxylated does not meet the criteria for classification as sensitising to the skin according to the CLP Regulation.

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not sensitising)

Respiratory sensitisation

Endpoint conclusion
Endpoint conclusion:
no study available

Justification for classification or non-classification

An assessment was conducted based on the properties of the indvidiual constituents of the substance. It concluded that Phenol, ethoxylated does not meet the criteria for classification as sensitising to the skin according to the CLP Regulation.