Registration Dossier

Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
disregarded due to major methodological deficiencies
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
documentation insufficient for assessment

Data source

Reference
Title:
Unnamed
Year:
1977

Materials and methods

Test guideline
Qualifier:
no guideline followed
GLP compliance:
not specified
Test type:
other: only one dose tested

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
Trithiocyanuric acid (TMT-H3)

Test animals

Species:
rabbit
Strain:
New Zealand White
Sex:
male

Administration / exposure

Type of coverage:
not specified
Vehicle:
unchanged (no vehicle)
Doses:
10.0 g/kg
No. of animals per sex per dose:
5
Control animals:
no

Results and discussion

Effect levels
Sex:
male
Dose descriptor:
LD50
Remarks on result:
not determinable due to absence of adverse toxic effects
Mortality:
died/dosed: 0/5
Clinical signs:
no signs of intoxication and no skin irritation noted
Gross pathology:
no gross pathology noted

Any other information on results incl. tables

mean bw, i: 2.69

mean bw, t: 2.94

Applicant's summary and conclusion

Interpretation of results:
study cannot be used for classification
Conclusions:
LD 50 estimated at greater than 10.0 g/kg.