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EC number: 629-080-0 | CAS number: 161308-34-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Flammability
Administrative data
Link to relevant study record(s)
- Endpoint:
- flammable solids
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 15 April 2019 - 08 May 2019
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.10 (Flammability (Solids))
- Version / remarks:
- 2016
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- UN Manual of Tests and Criteria: Test N.1 (Test method for readily combustible solids)
- Version / remarks:
- Rev. 6 (2015)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Specific details on test material used for the study:
- Test item is a powder.
- Key result
- Test procedure:
- burning rate test: preliminary screening test
- Remarks on result:
- other: The substance does ignite but does not propagate combustion either by burning with flame or smouldering
- Interpretation of results:
- other: not classified based on GHS or CLP criteria
- Conclusions:
- The substance is not a flammable solid.
- Executive summary:
A GLP study according to EC A.10 and UN Test N.1 was performed. In the preliminary screening test, the substance does ignite but does not propagate combustion either by burning with flame or smouldering along 200 mm of the test item pile within 2 minutes. The substance melted in contact with the flame. The substance is concluded to be not a flammable solid.
- Endpoint:
- pyrophoric solids
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- other:
- Justification for type of information:
- In a statement based on structural features (see below in quotes) it was concluded that the substance has no pyrophoric properties. Additionally study reports (e.g. for determination of density) do not mention any pyrophoric effect during handling the substance. In accordance with UN RTDG/MTC/Appendix 6/Screening procedures/Section 5.2 for substances which may be liable to spontaneous combustion, no further data are required.
Full statement as presented in the study report:
"A test item is considered pyrophoric when it ignites within five minutes of coming in contact with air. The molecular structure of the test item is shown in Paragraph 4.1. The test item does not contain groups that might lead to ignition in contact with air. Since the purity of the test item is determined at 99.94% (see Appendix 2), the impurities were not taken into account, as no effects from the impurities are expected. In conclusion, 4-(cyclohexylamino)butane-1-sulfonic acid has no pyrophoric properties." - Reason / purpose for cross-reference:
- data waiving: supporting information
- Endpoint:
- self-heating substances / mixtures
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 15 April 2019 - 08 May 2019
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- UN Manual of Tests and Criteria: Test N.4 (Test method for self-heating substances)
- Version / remarks:
- Rev. 6 (2015)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Specific details on test material used for the study:
- Particle size distribution: D10= 20.3 µm; D50= 74.7 µm; D90=143 µm
- Key result
- Test procedure:
- 100 mm sample cube at 140°C
- Result:
- negative outcome (no effect observed)
- Interpretation of results:
- other: not classified based on GHS or CLP criteria
- Conclusions:
- The substance is not self-heating.
- Executive summary:
In a GLP study according to UN Test N.4, a negative result was obtained using a 10 cm sample cube at 140°C. From this it was concluded that 4-(cyclohexylamino)butane-1-sulfonic acid is not a self-heating substance.
- Endpoint:
- substances / mixtures which in contact with water emit flammable gases
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- the study does not need to be conducted because the organic substance does not contain metals or metalloids and hence, the classification procedure does not need to be applied
- the study does not need to be conducted because the experience in production or handling shows that the substance does not react with water, e.g. the substance is manufactured with water or washed with water
- Justification for type of information:
- Statement as presented in the study report (see below in quotes) was based on the molecular structure of the substance (see Reference substance '4-(cyclohexylamino)butane-1-sulfonic acid').
In the water solubility study (see cross reference) there was no mentioning of any release of flammable gas.
In accordance with UN ST/SG/AC.10/11/Rev.6 (RTDG- Manual of Tests and Criteria) Appendix 6-Screening procedures/Section 5.3 for substances which in contact with water may react to emit flammable gases, no further data are required. The classification procedure for substances which may react with water to emit flammable gases does not need to be applied.
Full statement as presented in the study report:
"A test item is considered highly flammable when it ignites spontaneously in contact with water, or evolves a flammable gas at a minimum rate of ≥ 1 litre/kg of the substance per hour.
The molecular structure of the test item is shown in paragraph 4.1. The test item does not contain groups that might lead to ignition in contact with water and/or to the evolution of a flammable gas. Since the purity of the test item is determined at 99.94% (see Appendix 2), the impurities were not taken into account, as no effects from the impurities are expected.
In conclusion, 4-(cyclohexylamino)butane-1-sulfonic acid is considered ‘not highly flammable’ in contact with water." - Reason / purpose for cross-reference:
- data waiving: supporting information
- Reason / purpose for cross-reference:
- data waiving: supporting information
Referenceopen allclose all
The flame of the gas burner did ignite the test item pile. The test item melted, burned with a orange yellow flame and turned into a black residue. Grey smoke was observed. After removal of the ignition source, the flame extinguished after 3 seconds and no propagation of combustion was observed.
After the experiment, the consistency of the sample was unchanged, i.e. no reaction and/or decomposition of the test item was observed.
Description of key information
Not a flammable solid (EC A.10, UN Test N.1: preliminary screening test)
No pyrophoric properties (based on experience in handling and structural features).
Not highly flammable in contact with water (based on experience in handling and structural features).
Not a self-heating substance (UN Test N.4).
Key value for chemical safety assessment
- Flammability:
- not classified
Additional information
Justification for classification or non-classification
Classification or non-classification according to CLP Regulation (EC) No. 1272/2008:
Not a flammable solid (negative in UN Test N.1)
Not a pyrophoric solid (the substance lacks functional groups that would imply this hazard)
No classification for the hazard "Substances which in contact with water emits flammable gases' (the substance lacks functional groups that would imply this hazard)
Not a self-heating substance (negative UN Test N.4 at 140°C)
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