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EC number: - | CAS number: -
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
EC50 (48h) = 6.63 mg/l, based on nominal concentration
Key value for chemical safety assessment
Additional information
In the acute immobilization test with Daphnia magna (STRAUS), the effects of the test item were determined at the test facility according to OECD 202 (2004).
The study was conducted under semi-static conditions over a period of 48 hours withfiveconcentration levels of the test item of1.00 - 2.00 - 4.00 - 8.00 - 16.0 mg/Lin a geometric series with a separation factor of 2.
Twenty daphnids (divided into 4 replicates with 5 daphnids each) were exposed to each concentration level and the control.
The concentrations of the test item were analytically verified via spectrophotometric analysis in the fresh media at the start of the exposure and at the renewal of the test solutions (0 and 24 hours) as well as in the 24 hours old media at the renewal and at the end of the test (24 and 48 hours) in all concentration levels and in the control.
The measured concentrations of the test item in the fresh media were in the range of < LOQ to 116% at the start of the exposure (0 hours) and at the renewal (24 hours). The measured concentrations of the test item in the old media at the renewal and at the end of the test (24 and 48 hours) were in the range of < LOQ to 142%. The three lowest concentration levels could not be quantified, since the nominal test item concentrations were below the LOQ of the analytical method. The establishment of a method with a lower LOQ was not possible.
The EC10 / 50 / 100-values given in the table belowwere based on the nominal concentrations of the test item.
The validity criteria of the test guideline were fulfilled.
EC10 / 50 / 100-Values(based on the nominal test item concentrations)
Effect levels
|
Test duration [hours] |
VANADYL, BIS-2-HYDROXYACETATE Nominal test item concentrations [mg/L] |
EC10 (with 95% confidence limits) |
24 |
15.5 (95% Cl: 8.10 – > 16.0) |
48 |
4.55 (95% Cl: 3.88 – 5.52) |
|
EC50 (with 95% confidence limits) |
24 |
> 16.0 (95% Cl: not applicable) |
48 |
6.63 (95% Cl: 5.94 – 7.09) |
|
EC100 |
24 |
> 16.0 |
48 |
16.0 |
Based on the nominal concentration levels of the test item, the 48 hours-EC50for Daphnia magna was 6.63mg/L (95% confidence limits: 5.94 – 7.09 mg/L).
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