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EC number: 439-730-3
CAS number: -
After a single application to the intact
dorsal skin of rabbits, for a 4 hours period of exposure under
semiocclusive conditions, no signs of irritation were observed in the
treated areas. No signs of clinical toxicity were detected.
All animals survived the observation period.
Body weight development of the treated
rabbits was inconspicuous.
Table 1 Individual findings
Mean score (24, 48, 72 h)
Maximum value (24, 48, 72 h)
The purpose of this assay was to identify
the skin irritation/corrosion potential of the test item when applied to
the intact skin of previously shaven rabbits for a 4 hours period under
semiocclusive conditions. This study should provide a rational basis for
risk assessment to the irritating potential of the test item in man. To
test for primary skin irritation, the test item was mixed with some
drops of Aqua pro injectione to ensure good contact to the skin.
Afterwards the test material was spread onto patches and applied to the
intact skin of three previously shaven rabbits for a 4 hours period
under semiocclusive conditions. The first examination of the treated
skin sites followed 1 hour after removal of the patches. Then,
examinations were performed daily for further 7 days. Under the
conditions of the present study no signs of irritation were seen. The
evaluation of all animals yields a zero mean score. The test item was
not irritating to the skin in this assay.
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