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Partition coefficient

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Reference
Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
26 MAY 2009 - 30 JUL 2009
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to
Guideline:
EU Method A.8 (Partition Coefficient)
Deviations:
no
Qualifier:
according to
Guideline:
OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
Deviations:
no
Qualifier:
equivalent or similar to
Guideline:
OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
Version / remarks:
Shake-flask method used for preliminary estimation
Deviations:
no
GLP compliance:
no
Type of method:
HPLC method
Partition coefficient type:
octanol-water
Analytical method:
high-performance liquid chromatography
Type:
log Pow
Partition coefficient:
> 6.5
Temp.:
25 °C
pH:
6.6
Details on results:
According to this preliminary test the solubility of the test item in n-octanol is > 1048 g/L.

Dead time: t0 = 2.71 min.

Calibration data:
Regression: log Pow = a + b log k
Parameter: a = 4.08, b = 3.76, r^2 = 0.9190

log Pow of the test substance
1st injection: tR = 38.0 min
2nd injection: tR = 38.4 min
mean: tR = 38.2 min
k = 13.1
log k > 0.37 (above log Pow value of the highest calibration substance (DDT)) - (1.12 - via extrapolation)
log Pow = > 6.5 (above log Pow value of the highest calibration substance (DDT)) - (8.3 - via extrapolation)
Conclusions:
The log Pow of the test was found to be > 6.5.
Executive summary:

The log POW of the sample was tested according to EU Method A.8 and OECD Guideline 117 in a non-GLP study at 25 °C and at a pH of 6.6. The log POW is > 6.5, which is the value of the highest calibration substance. Via extrapolation a value of 8.3 was received as log POW.

Description of key information

The log POW of the sample was tested according to EU Method A.8 and OECD Guideline 117 in a non-GLP study at 25 °C and at a pH of 6.6. The log POW is > 6.5, which is the value of the highest calibration substance. Via extrapolationa a value of 8.3 was received as log POW.

Key value for chemical safety assessment

Log Kow (Log Pow):
8.3
at the temperature of:
25 °C

Additional information