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Description of key information

Acute Oral toxicity

Rat: LD50 (m/f) > 2200 mg/kg bw (EU B.1; BASF AG, 1993)

Rat:LD50 (m/f) > 5000 mg/kg bw (OECD 401; BASF AG, 1984)

            

Key value for chemical safety assessment

Acute toxicity: via oral route

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed
Dose descriptor:
LD50
Value:
2 200 mg/kg bw

Additional information

The following considerations based on EC 400 -720 -9 are also applicable to EC: 700- 899 -6. For read across justification see the relevant document in the read across section

There are valid, guideline conform, in vivo data available for the assessment of the acute toxicity of the test substance.

Acute Oral toxicity

The acute oral toxicity of the test substance was investigated in two groups of 3 male and 3 female rats according to EU B.1/OECD 401 guideline, given a limit dose of 2200 mg/kg bw as gavage. Clinical signs were discoloured feces for male and female rats and piloerection and smeared fur in the anogenital area in male animals. No mortality or gross pathological changes were reported.

In the second study the acute oral toxicity of the test substance was investigated according to OECD guideline 401 in two groups of 3 male and 3 female rats, given a limit dose of 5000 mg/kg bw as gavage. Clinical signs were black feces for male and female rats. No mortality or gross pathological changes were reported.

 

Acute Inhalation toxicity

The acute dust inhalation toxicity of the test substance was investigated according to OECD 403 guideline in 5 male and 5 female rats. The test material was applied as dust (dust generator; dose determination: gravimetrically) via head/nose inhalation at a limit dose level of 5200 mg/m3 for 4 hours. Clinical signs during exposure were attempts to escape and irregular breathing. After exposure no deaths and no signs of toxicity were noted.

 

Acute Dermal toxicity

Appropriate data to assess the acute dermal toxicity of the test article are not available.

Justification for classification or non-classification

The following considerations based on EC 400 -720 -9 are also applicable to EC: 700- 899 -6. For read across justification see the relevant document in the read across section

Acute Oral toxicity

Based on the criteria defined by the EU and the GHS system, the test substance needs not to be labelled for acute oral toxicity because no death occurred in the highest dosing group of 5000 mg/kg bw in male and female animals that could be attributed to the test substance administration.

Acute Inhalation toxicity

For acute inhalation toxicity the test substance needs also not to be labelled according to the criteria defined by the EU and the GHS system since no death occurred at the highest dose level of 5200 mg/l.

Acute Dermal toxicity

Actually, there is no indication given for a classification according to this endpoint

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