β-methyl-3-(1-methylethyl)benzenepropanal

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Study period:

1988

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1988

Report date:

1988

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

OECD Guideline 401 (Acute Oral Toxicity)

GLP compliance:

yes

Test type:

acute toxic class method

Limit test:

yes

Test material

Test material information

Constituent 1

Reference substance name:

β-methyl-3-(1-methylethyl)benzenepropanal

EC Number:

412-050-4

EC Name:

β-methyl-3-(1-methylethyl)benzenepropanal

Cas Number:

125109-85-5

Molecular formula:

C13H18O

IUPAC Name:

3-[3-(propan-2-yl)phenyl]butanal

Test material form:

liquid

Specific details on test material used for the study:

Degree of purity: 95.4%
Physical condition: Liquid
Lot number: 8906-87

Test animals

Species:

rat

Strain:

other: Ibm: RORO (SPF)

Sex:

male/female

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

unchanged (no vehicle)

Doses:

2000 mg/kg bw

No. of animals per sex per dose:

5

Control animals:

not specified

Results and discussion

Effect levels

Sex:

male/female

Dose descriptor:

LD50

Effect level:

> 2 000 mg/kg bw

Based on:

test mat.

Mortality:

none

Clinical signs:

other: none

Gross pathology:

no effects

Applicant's summary and conclusion

Interpretation of results:

not classified

Remarks:

Migrated information Criteria used for interpretation of results: EU

Conclusions:

The acute oral toxicity of benzenepropanal, .beta.-methyl-3-(1-methylethyl)- is greater than 2000 mg/kg bodyweight in male and female rats.

Executive summary:

Ten outbred stock, Ibm: RORO (SFP) animals (5 males and 5 females) were used. Animals were approximately 5-6 weeks old. Males weighed 107-131 grams and females weighed 112-119 grams. Animals wer housed individually in an air conditioned room. Room temperature was 20-24 C with relative humidity of 45-65% and an artificial light cycle of 12 hour darkness and 12 hours light per day. Food and water were available ad libitum except 18 hours prior to dosing where the animals were fasted. A single dose of test material in Standard Suspending Vehicle (SSV) was administered to each animal. Animals were observed for daily for 15 days for toxic signs including mortality and body weight changes. Bodyweights were recorded on days 0, 4, 7, 12 and 15. Gross necropsies were conducted on all animals

100 ml SSV contained: 5 grams sodium carboxymethyl cellulose of median viscosity, 4 ml Tween 80, 5 ml benzylalcohol pro analysi, 9 grams sodium-chloride pro analysi, aqua destillata ad 1000 ml.

The acute oral toxicity of benzenepropanal, .beta.-methyl-3-(1-methylethyl)- is greater than 2000 mg/kg bodyweight in male and female rats. No deaths occurred. No effect on bodyweight was observed. No findings at necropsy.