Registration Dossier
Registration Dossier
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EC number: 412-050-4 | CAS number: 125109-85-5 FLORHYDRAL
Endpoint summary
Administrative data
Description of key information
BIOCONCENTRATION :
Predictive QSAR models (EPISuite BCFBAF, OASIS-CATALOGIC BCF BaseLine) indicate that FLORHYDRAL has a low potential to bioaccumulate in fish. The latter model indicated that the metabolism step would derive the Florhydral-Acid in the first instance.
In addition to this, an In vitro metabolism study using Rainbow Trout liver S9 (equivalent to the OECD 319B Test Guideline) was performed to determine the metabolism kinetics of FLORHYDRAL and establish the intrinsic clearance rate (CLint). This assay illustrated > 90% metabolic turnover of FLORHYDRAL within 20 minutes of exposure. Both Florhydral-Acid and Florhydral-Alcohol were identified as metabolites as was the glucuronide conjugate of the alcohol derivative. This assay further confirmed the low potential to bioaccumulate of FLORHYDRAL.
Additional information
BIOCONCENTRATION :
Predictive QSAR models (EPISuite BCFBAF, OASIS-CATALOGIC BCF BaseLine) indicate that FLORHYDRAL has a low potential to bioaccumulate in fish. The latter model indicated that the metabolism step would derive the Florhydral-Acid in the first instance.
In addition to this, an In vitro metabolism study using Rainbow Trout liver S9 (equivalent to the OECD 319B Test Guideline) was performed to determine the metabolism kinetics of FLORHYDRAL and establish the intrinsic clearance rate (CLint). This assay illustrated > 90% metabolic turnover of FLORHYDRAL within 20 minutes of exposure. Both Florhydral-Acid and Florhydral-Alcohol were identified as metabolites as was the glucuronide conjugate of the alcohol derivative. This assay further confirmed the low potential to bioaccumulate of FLORHYDRAL
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