Registration Dossier

Diss Factsheets

Ecotoxicological information

Endpoint summary

Administrative data

Description of key information

Short-term, toxicity to fish

Key, fish acute toxicity, Danio rerio, limit test, OECD 203, semi-static, GLP: LC50 (96h) > 100 mg/L nominal

Short-term toxicity to aquatic invertebrates

Key, acute immobilisation, Daphnia magna, limit test, OECD 202, semi-static, GLP: EC50 (48h) > 0.88 µg/L geometric mean measured, EC50 (48h) > 100 mg/L nominal

Toxicity to aquatic algae and cyanobacteria

Key, growth rate inhibition, Raphidocelis subcapitata (formerly known as Pseudokirchneriella subcapitata), limit test, OECD 201, GLP: ECr50 (72h) > 13.0 µg/L geometric mean measured and > 100 mg/L nominal, ECr10 (72h) > 13.0 µg/L geometric mean measured and > 100 mg/L nominal

Toxicity to microorganisms

Key, OECD 209, GLP, static, results: EC10(3h) 53.4 mg/L (nominal) and EC50 (3h) > 1000 mg/L (nominal)

Additional information

No acute toxicity is recorded at levels up to the water solubility. But taking in account the very low solubility (below 2 μg/L at 20 °C) of the test item and the very poor biodegradation (0.4 % at 28d) as well as the potential to bioaccumulate (log Kow 9.674), the substance should be classified as H413 “May cause long lasting harmful effects to aquatic life” (Category Chronic 4) in accordance with Regulation (EC) No 1272/2008, unless other data exists showing classification to be unnecessary.

This "safety net" classification includes poorly soluble substances for which no acute toxicity is recorded at levels up to the water solubility, and which are not rapidly degradable and have an experimentally determined BCF ≥ 500 (or, if absent, a log K ow ≥ 4), indicating a potential to bioaccumulate. This classification is also recommended in OECD Guidance Document No. 27 based on the outlined criteria.