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Vapour pressure

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Reference
Endpoint:
vapour pressure
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2019-03-11
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to
Guideline:
OECD Guideline 104 (Vapour Pressure Curve)
Deviations:
no
Qualifier:
according to
Guideline:
EU Method A.4 (Vapour Pressure)
Deviations:
no
GLP compliance:
no
Type of method:
dynamic method
Test no.:
#1
Temp.:
20 °C
Vapour pressure:
3 Pa
Key result
Test no.:
#2
Temp.:
25 °C
Vapour pressure:
5 Pa
Test no.:
#3
Temp.:
50 °C
Vapour pressure:
39 Pa

The vapour pressure was measured in the temperature range of 109.6 to 148.1 °C.

Results of the dynamic method

No.

Temperature / °C

Vapour pressure/ hPa

Rem ark

1

109.6

15.2

measured up

2

119.3

29.6

measured up

3

128.6

44.4

measured up

4

134.8

59.6

measured up

5

140.5

74.6

measured up

6

148.1

99.2

measured up

7

142.3

81.1

measured down

8

135.1

62.1

measured down

g

122.9

37.8

measured down

 

From the measured data points of the vapour pressure curve the constants A, B and C of the Antoine equation was derived by regression of the data points to A = 12.0288; B = -3371.47; C = 273.15. The vapour pressure of the test item was calculated by extrapolation of the measured vapour pressure curve for the temperatures 20, 25 and 50°C.

Calculated vapour pressure values for 20, 25 and 50 °C

Temperature/ °C

Vapour pressure / hPa

20

0 03

25

0 05

50

0 39

Conclusions:
The vapour pressure of the test item was determined to be 3 Pa at 20 °C, 5 Pa at 25 °C and 39 Pa at 50 °C respectively.
Executive summary:

A study was conducted according to OECD TG 104, Regulation (EC) No 440/2008 method A.4 to determine the vapour pressure of the test item. A vapour pressure curve with 9 data points was measured over a pressure range between 15.2 to 37.8 hPa. For control 3 measuring points were evaluated with decreasing pressure. The vapour pressure was measured in the temperature range of 109.6 to 148.1 °C. From the measured data points of the vapour pressure curve the constants A, B and C of the Antoine equation was derived and the vapour pressure of the test item was calculated by extrapolation of the measured vapour pressure curve for the temperatures 20, 25 and 50 °C, according to Regulation EC No. 440/2008 Method A.4. The vapour pressure was determined to be 3 Pa at 20 °C, 5 Pa at 25 °C and 39 Pa at 50 respectively.

Description of key information

The vapour pressure of the test item was determined to be 3 Pa at 20 °C, 5 Pa at 25 °C and 39 Pa at 50 °C respectively.

Key value for chemical safety assessment

Vapour pressure:
3 Pa
at the temperature of:
20 °C

Additional information

A study was conducted according to OECD TG 104, Regulation (EC) No 440/2008 method A.4 to determine the vapour pressure of the test item. A vapour pressure curve with 9 data points was measured over a pressure range between 15.2 to 37.8 hPa. For control 3 measuring points were evaluated with decreasing pressure. The vapour pressure was measured in the temperature range of 109.6 to 148.1 °C. From the measured data points of the vapour pressure curve the constants A, B and C of the Antoine equation was derived and the vapour pressure of the test item was calculated by extrapolation of the measured vapour pressure curve for the temperatures 20, 25 and 50 °C, according to Regulation EC No. 440/2008 Method A.4. The vapour pressure was determined to be 3 Pa at 20 °C, 5 Pa at 25 °C and 39 Pa at 50 respectively.