Registration Dossier

Physical & Chemical properties

Water solubility

Currently viewing:

Administrative data

Link to relevant study record(s)

Reference
Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
14th January 1993 to 18th May 1994
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to
Guideline:
OECD Guideline 105 (Water Solubility)
Deviations:
no
Qualifier:
according to
Guideline:
EU Method A.6 (Water Solubility)
Deviations:
no
GLP compliance:
yes
Type of method:
flask method
Key result
Temp.:
20 °C
Remarks on result:
not determinable
Remarks:
the substance formed a stable emulsion throughout the concentration range of 6 to 10000 g/L
Details on results:
The water solubility of the test material could not be determined. The test material formed a stable emulsion in water.
The critical micelle concentration (CMC) was not determined.

Table 1: Results from run 1 (Addition of test material to 10 mL of water)

Weight of test substance
(mg)

Concentration
(mg/mL)

Observations

60

6

After stirring, a foam formed

460

52

Foam took on colour of test substance, some residual test substance

350

87

Agter standing one hour, no water remained, only foam

460

133

After mixing, foam thickened.

3110

444

Thickening continued

With further test substance additions up to approximately 10 g (1000 mg/mL) the foam continued to thicken and remain stable.

 

Table 2: Addition of water to 10.17 g of test material

Incremental volume of water adder
(mL)

Concentration

(mg/mL)

Observations

0.1

(up to 1 mL total)

≥ 10170

Water 'absorbed' by test substance

1

10170

Cloudy mixture

1

5085

Liquid coloured at test substance plus white foam

2

2543

No change from above after one hour

With increasing water additions, foam continued to form, with presence of some residual test material

Conclusions:
The shake flask method was used to attempt to produce saturated solutions of the test material in water. It was not possible at the test substance formed a stable emulsion throughout the concentration range of 6 to 10000 g/L.
Executive summary:

The water solubility of the test material was determined in a study conducted in accordance with EU Method A.6 and OECD Guideline 105. The study was performed using the shake flask method. It was not possible to determine the water solubility from the current study as the test substance formed a stable emulsion throughout the concentration range of 6 to 10000 g/L. The critical micelle concentration (CMC) was not determined.

Description of key information

The water solubility of the test material was determined in a study conducted in accordance with EU Method A.6 and OECD Guideline 105. The study was performed using the shake flask method. It was not possible to determine the water solubility from the current study as the test substance formed a stable emulsion throughout the concentration range of 6 to 10000 g/L. The critical micelle concentration (CMC) was not determined.

Key value for chemical safety assessment

Additional information