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Ecotoxicological information

Endpoint summary

Administrative data

Description of key information

The ecotoxicity data in this dossier from Sodium salts of substituted amino acid are read across from Substituted amino acid (2) solution. This read across is considered to be justified because Substituted amino acid (2) solution contains about 50% of Substituted amino acid (i.e.the L stereo isomer of Substituted amino acid (2) solution) and no ecotoxicity (EC50>100 mg/L) was observed for Substituted amino acid (2) solution in the acute daphnia and algae test. There will be no significant difference in ecotoxicity of Substituted amino acid or Sodium salts of substituted amino acid because test substances are tested in very diluted form in buffered matrixes. It is therefore considered extremely unlikely that any significant aquatic ecotoxicity will be observed for Sodium salts of substituted amino acid.

Additional information

The ecotoxicity data in this dossier from Sodium salts of substituted amino acid are read across from Substituted amino acid (2) solution. This read across is considered to be justified because Substituted amino acid (2) solution contains about 50% of Substituted amino acid (i.e.the L stereo isomer of Substituted amino acid (2) solution) and no ecotoxicity (EC50>100 mg/L) was observed for Substituted amino acid (2) solution in the acute daphnia and algae test. There will be no significant difference in ecotoxicity of Substituted amino acid or Sodium salts of substituted amino acid because test substances are tested in very diluted form in buffered matrixes. It is therefore considered extremely unlikely that any significant aquatic ecotoxicity will be observed for Sodium salts of substituted amino acid.

Substituted amino acid (2) solution or DL-ALDN-acid is structurally identical to Substituted amino acid (or L-ALDN-acid) only the order in which the different groups are placed around the chiral carbon is different. No ecotoxicity (EC50>100 mg/L) was observed for DL-ALDN-acid in the acute daphnia and algae test. It is therefore extremely unlikely that any significant aquatic ecotoxicity will be observed for L-ALDN-acid.

For substituted amino acid (2) solution, which is an industrial intermediate substance, two aquatic ecotoxicity test results are available and information on the inhibition of micro-organisms presented in activated sludge and in river water.

Based on the results of a short-term aquatic toxicity study, performed according to OECD 201 and GLP principles, substituted amino acid (2) solution inhibited growth of Pseudokirchneriella subcapitata at analytically confirmed nominal concentrations of 18 mg/L and higher. Based on biological relevance, the 72 h-NOErC was determined to be 100 mg/L. The 72 h-ErC50 and 72h-ErC10 and NOEC were determined to be >100 mg/L.

 

Based on the results of a short-term aquatic toxicity study, performed according to OECD 202 and GLP principles, substituted amino acid (2) solution showed no toxicity towards Daphnia magna in a 48 hour exposure period when tested up to a limit concentration of 100 mg/L. Therefore, the 48h-EC50 was determined to exceed an analytically confirmed nominal concentration of 100 mg/L.

 

The toxicity of substituted amino acid (2) solution FC-C 13587 to activated sludge was determined according to OECD 209 under GLP conditions at a contact time of 3 hours, using various concentrations of the test substance. The inhibitory effect of substituted amino acid (2) solution FC-C 13587 at a particular concentration is expressed as a percentage of the two controls. From the results EC values were calculated. The EC10 of substituted amino acid (2) solution FC-C 13587 for activated sludge after 3 hours contact time is 164.3 mg a.i./L with 95% confidence limits of 76.7 and 815.4 mg/L. The EC20, EC50 and EC80 of substituted amino acid (2) solution FC-C 13587 for activated sludge could not be determined. Substituted amino acid (2) solution FC-C 13587 is therefore considered not harmful to activated sludge.