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EC number: 947-652-0
CAS number: 943986-70-7
An Ames test was performed equivalent to OECD 471 guideline and GLP
In the dose-range finding study, the test item was tested up to and
including concentrations of 5000 μg/plate in strain TA100 in the
pre-incubation assay. The substance did not precipitate on the plates at
this dose level and the bacterial background lawn was not reduced at any
of the concentrations tested.
In the mutation experiments, the test item was tested up to and
including concentrations of 5000 μg/plate in the tester strains TA1535,
TA1537, TA98, TA100 and WP2uvrA in the pre-incubation assay. The test
item did not precipitate on the plates at this dose level and no
cytotoxicity was observed.
The negative and strain-specific positive control values were within the
laboratory historical control data ranges indicating that the test
conditions were adequate and that the metabolic activation system
All bacterial strains showed negative responses over the entire dose
range, i.e. no significant dose-related increase in the number of
revertants in independently repeated experiments. In conclusion, based
on the results of this study it is concluded that the substance is not
mutagenic in the Salmonella typhimurium reverse mutation assay and in
the Escherichia coli reverse mutation assay.
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