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Administrative data

Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
28 Jan 2019 - 20 Feb 2019
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
comparable to guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2019

Materials and methods

Test guidelineopen allclose all
Qualifier:
equivalent or similar to guideline
Guideline:
EU Method A.6 (Water Solubility)
Version / remarks:
2016
Deviations:
no
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 105 (Water Solubility)
Version / remarks:
1995
Deviations:
no
Qualifier:
equivalent or similar to guideline
Guideline:
EPA OPPTS 830.7840 (Water Solubility)
Version / remarks:
1998
Deviations:
no
Principles of method if other than guideline:
In a preliminary test the substance was found to be very well soluble so the main study was not performed.
GLP compliance:
yes
Type of method:
flask method

Test material

Constituent 1
Chemical structure
Reference substance name:
Reaction mass of (S)-2-[(R)-2-Oxo-4-propyl-1-pyrrolidinyl]butyramide and (S)-2-[(S)-2-Oxo-4-propyl-1-pyrrolidinyl]butyramide
Cas Number:
943986-70-7
Molecular formula:
C11H20N2O2
IUPAC Name:
Reaction mass of (S)-2-[(R)-2-Oxo-4-propyl-1-pyrrolidinyl]butyramide and (S)-2-[(S)-2-Oxo-4-propyl-1-pyrrolidinyl]butyramide
Test material form:
solid
Details on test material:
- Appearance: Off-white solid
- Storage condition of test material: At room temperature protected from light

Results and discussion

Water solubility
Key result
Water solubility:
> 1 000 g/L
Conc. based on:
test mat.
Loading of aqueous phase:
1 110
Incubation duration:
1 h
Temp.:
20.1 °C
Remarks on result:
completely miscible
Details on results:
After the stirring period, the test solution was clear and visually no undissolved test item was observed.
It was concluded that the water solubility of the test item at 20°C was > 1 x 10^3 g/L.

Applicant's summary and conclusion

Conclusions:
The water solubility of the substance at 20°C was determined to be > 1000 g/L (flask method).

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