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EC number: -
CAS number: -
The preliminary test at room temperature showed, that the water
solubility of the test item was between 169.5 and 1,016.7 g/L. The
observations of the preliminary test are summarized in Table 1.
Table 1: Preliminary test for the water solubility
Amount of test item [mg]
Total volume of added water [mL]
Time in ultrasonic bath [min]
The solubility of the test item in water at room temperature was
estimated to be between 169.5 and 1,016.7 g/L. Due to this result, the
flask method was performed.
Main Test (flask method)
For the main test three flasks were prepared with an amount of test item
and water, and one flask only with water. After stirring and
centrifugation the aqueous phases were dilutedwith double distilled
waterand measured by means of HPLC. The solution of each flask has been
measured twice. The results of these measurements are shown in Table 2.
The values represented in the table are rounded values. The calculation
was carried out with the original not rounded values.
Table 2: Results of the flask method
1a (72 h)
2a (48 h)
3a (24 h)
4a (72 h)
measured value [mg/L]
774.1 / 770.5
794.8 / 791.9
821.8 / 817.1
0 / 0
aliquot of the flask [mL]
total volume after dilution [mL]
water solubility [g/L]
77.41 / 77.05
79.48 / 79.19
82.18 / 81.71
average water solubility [g/L]
mean value of the water solubility [g/L]
standard deviation [g/L]
relative standard deviation [%]
To verify the accuracy of the analytical method freshly prepared
standard solutions (prepared with the test item) were measured in
between the samples of the flask method. The results of these
measurements are shown in Table 3.
Table 3: Measurements of standard solutions
(nominal value [mg/L])
Measured value [mg/L]
The recovery rate of the measured standard solutions was in the range
from 99.4 % to 100.3%, which shows a good accuracy of the analytical
According to OECD Test Guideline 105 (1995) and Regulation EC
No. 440/2008 Method A.6. the water solubility at 20 °C of the test item
DMPSA-K2 was determined to be:
cS = 79.5 g/L
RSD = 3.0 %
79.5E03 mg/L at 20 °C (flash method, OECD 105)
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