Registration Dossier
Registration Dossier
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EC number: 201-051-3 | CAS number: 77-71-4
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- The ganglioplegic effect of 3-alkylaminoalkyl-hydantoins
- Author:
- STILLE G, BRUNCKOW I.
- Year:
- 1 954
- Bibliographic source:
- Arzneimittel-Forschung. Drug Research. Vol. 4, Pg. 723, 1954.
Materials and methods
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 5,5-dimethylhydantoin
- EC Number:
- 201-051-3
- EC Name:
- 5,5-dimethylhydantoin
- Cas Number:
- 77-71-4
- Molecular formula:
- C5H8N2O2
- IUPAC Name:
- 5,5-dimethylimidazolidine-2,4-dione
- Details on test material:
- Identity: 5,5-Dimethylhydantoin (CAS RN 77-71-4)
Purity: No information provided
Constituent 1
- Specific details on test material used for the study:
- Identity: 5,5-Dimethylhydantoin (CAS RN 77-71-4)
Purity: No information provided
Test animals
- Species:
- mouse
- Strain:
- New Zealand White
- Sex:
- not specified
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- not specified
- Details on dermal exposure:
- The route of exposure specified is the subcutaneous one. As a conservative assumption the subcutaneous route was use for the evaluation of the acute dermal toxicity of the substance.
- Control animals:
- not specified
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 2 800 mg/kg bw
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The route of exposure specified is the subcutaneous one. As a conservative assumption, the subcutaneous route was used for the evaluation of the acute dermal toxicity of the substance.
The acute dermal LD50 for 5,5-Dimethylhydantoin was determined to be 2800 mg/kg in mouse.
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