Registration Dossier
Registration Dossier
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EC number: 200-293-7 | CAS number: 56-86-0
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- other: SIDS
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- SIDS for L-Glutamic acid
- Author:
- OECD
- Year:
- 2 013
- Report date:
- 2013
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 983
Materials and methods
- Principles of method if other than guideline:
- Intercomparison Study on the Determination of Single Administration Toxicity in Rats, Commission of the European Communities, Health and Safety
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Specific details on test material used for the study:
- Test material equivalent to submission substance identity:
yes
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Winkelmann, Borchen
- Age at study initiation: male 48~5 days, female 62 days
- Weight at study initiation: male 129~166 g, female 131~141 g
- Fasting period before study: 16 hours
- Housing: individually in makrolon cages type II
- Diet: ad libitum
- Water: ad libitum
- Acclimation period: 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (℃): 21
- Humidity (%): 55
- Photoperiod (hrs dark / hrs light): 12/12
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: tragacanth
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 5 110 mg/kg bw
- Remarks on result:
- other: no mortality and body weight changes were observed
- Mortality:
- After the observation period none of the animals died after dosing of 5,110 mg/kg.
- Clinical signs:
- other: No signs of toxicity was observed at the animals after dosing of 5,110 mg/kg
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- L-Glutaminic acid is not classified as toxic via oral route.
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