Registration Dossier
Registration Dossier
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EC number: 936-560-6 | CAS number: 212070-45-6
Surface tension
Administrative data
- Endpoint:
- surface tension
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with generally accepted scientific standards and described in sufficient detail
Data source
Reference
- Reference Type:
- publication
- Title:
- Molecular associations and surface-active properties of short- and long-N-acyl chain ceramides
- Author:
- Sot et al.
- Year:
- 2 005
- Bibliographic source:
- Biochimica et Biophysica Acta 1711 (2005) 12–19. doi:10.1016/j.bbamem.2005.02.014
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Langmuir balance and fluorescence techniques
- GLP compliance:
- not specified
- Type of method:
- other: Determination of equilibrium values in surface pressure at an air–water interface
Test material
- Reference substance name:
- 2-hydroxy-N-((2S,3S,4R)-1,3,4-trihydroxyoctadecan-2-yl)octadecanamide
- Cas Number:
- 212070-45-6
- Molecular formula:
- C36H73NO5
- IUPAC Name:
- 2-hydroxy-N-((2S,3S,4R)-1,3,4-trihydroxyoctadecan-2-yl)octadecanamide
- Test material form:
- solid: crystalline
Constituent 1
- Specific details on test material used for the study:
- Ceramides were supplied by Avanti Polar Lipids (Alabaster, AL). All lipids were > 98 % pure as supplied and were used without further purification. All other reagents were of analytical grade.
Results and discussion
Surface tension
- Key result
- Remarks on result:
- not determinable
- Remarks:
- A ceramide with C16 was not modifying the surface pressure of the aqueous solutions into which it was included.
Applicant's summary and conclusion
- Conclusions:
- Long-N-acyl chain ceramides (C≥16) do not cause a change in surface pressure.
- Executive summary:
According to the study by Sot et al. (2005), long-N-acyl chain ceramides (C≥16) are highly hydrophobic and essentially insoluble and non-dispersible in water. Their studies show that long-chain ceramides belong in the category of insoluble non-swelling amphiphiles, implying that they cannot give rise to micelles or other hydrated aggregates in water suspension.
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