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EC number: 949-745-1
CAS number: -
Table 1 Characteristics of the kinetics of TEHTM and its metabolites in
blood after oral exposure to 1.12 mg/kg body weight TEHTM (mean value; n
= 4 volunteers)
The metabolism and excretion kinetics of
TEHTM, a substitute for high molecular weight plasticizers such as DEHP,
was investigated in four human volunteers. The results show that TEHTM
is resorbed and metabolized in the human body, after oral exposure.
Here, a pronounced regioselective ester hydrolysis of TEHTM in blood was
observed, as well for the primary diester metabolites (DEHTM), as for
the primary monoester metabolites (MEHTM). The same applies for the
investigated urinary metabolites of TEHTM, where the most prominent
urinary biomarker was found to be 2-MEHTM, followed by several specific
secondary metabolites. All in all, approximately 5.8% of the orally
administered dose was recovered in urine over a period of 72 h. The
results of this study indicate that the resorption rate of TEHTM in
humans is comparatively low, combined with an apparently rather slow
metabolism and excretion rate as TEHTM and selected metabolites were
still detectable in blood and urine after 48 h and 72 h postexposure,
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