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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Ecotoxicological information

Short-term toxicity to fish

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Administrative data

Link to relevant study record(s)

Description of key information

The substance is acutely harmful to fish.

Key value for chemical safety assessment

Additional information

This endpoint is not an information requirement for the tonnage band of the substance: 1 -10 tpa non-intermediate.

However, for the assessment of the substance available experimental and valid estimated data were used in a weight-of-evidence approach.

There is only one experimental result available. In a range-finding test within a bioaccumulation study by NITE (J-CHECK, 2018), a 48-h LC50 of mg/L was determined for Oryzias latipes. No further information on this result are available. It should be noted that the exposre period is too short compared to the standard exposure period of current guidelines (48 instead of 96 h).

The estimated LC50 values are in a range from > 10 to 306 mg/L. Only results from models where the substance was within the applicabilty domain of the model were used.

The following estimated LC50 values from valid QSAR models were used:



96-h LC50 (mg/L)



VEGA v.1.1.3

Fish Acute (LC50) Toxicity classification (SarPy/IRFMN) 1.0.2

>10 to < 100



US EPA TEST v4.2.1

Fathead minnow LC50 (96hr)



Based on the mean absolute errors of the models the confidence in the predicted results is high.

EPI Suite v4.11

ECOSAR v1.11: Fish



ECOSAR class: Aliphatic amines

QSAR Toolbox v4.3.1

Automated workflow for estimation of EC50/LC50 for fish




Following a worst case assessment, it can be concluded that the substance is acutely harmful to fish (LC50 > 10 mg/L).