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Vapour pressure

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Reference
Endpoint:
vapour pressure
Type of information:
experimental study
Adequacy of study:
key study
Study period:
03 APR 2000 - 21 JUN 2000
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Reason / purpose for cross-reference:
reference to same study
Reason / purpose for cross-reference:
reference to same study
Reason / purpose for cross-reference:
reference to same study
Qualifier:
according to guideline
Guideline:
EU Method A.4 (Vapour Pressure)
Version / remarks:
Guuideline 92/69/EEC of 31 July 1992
Deviations:
no
GLP compliance:
yes
Type of method:
effusion method: vapour pressure balance
Temp.:
25 °C
Vapour pressure:
< 0 Pa
Remarks on result:
other: The vapour pressure at 20 and 50°C is also below the reported value.

As a precaution a Differential Scanning Calorimetry (DSC) was performed. The measurement in a closed glass pan shows an endothermal effect (melting) in the range 50-90 °C and an exothermal decomposition in the range 185-310 °C, with a decomposition energy of 268 J/g and a second one in the range 355-450 °C, with a decomposition energy of 328 J/g.

The vapour pressure was measured in the temperature range of 19.5 °C to 148.5 °C.

In the temperature range 19.5 °C up to 105 °C no increase in weight and therefore novapour pressure of the test substance was registered.

The signals in the range 105.3 °C up to 148.5 °C were near the lower measuring limit and showed a course which is untypical for a vapour pressure / temperature dependence.

The following table shows the measured pressure data at the corresponding temperatures.

 Temperature [°C]  Vapour pressure [hPa]
 103.3  8.6 x 10-6
 111.2  2.6 x 10-5
 114.5  2.2 x 10-5
 119.0  2.6 x 10-5
 124.9  2.7 x 10-5
 128.5  2.7 x 10-5
 134.5  2.7 x 10-5
 140.3  2.3 x 10-5
 145.9  2.7 x 10-5
 148.5  1.8 x 10-5

The figure (attached as background material) gives the logarithm of vapour pressure as a function of the inverse temperature (1/T, T in Kelvin). Only for better readability the temperature is reported in centigrade scale.

Conclusions:
The vapour pressure at 20, 25 or 50 °C can be assumed to be below 3 x 10E-5 hPa.
Executive summary:

The vapour pressure was determined according to Guideline 92/69/EEC A.4 under GLP conditions. The vapour pressure at 20, 25 or 50 °C can be assumed to be below 3 x 10-5 hPa.

Description of key information

The vapour pressure was determined according to Guideline 92/69/EEC A.4 under GLP conditions. The vapour pressure at 20, 25 or 50 °C can be assumed to be below 3 x 10-5hPa.

Key value for chemical safety assessment

Vapour pressure:
0 hPa
at the temperature of:
25 °C

Additional information

The real vapour pressure is below the above mentioned value, because no change in sample weight was measured at temperatures between 19.5 and 105 °C. Therefore real vapour pressure at a temperature of 25 °C must be lower than the vapour pressure determined from a temperature of 105 °C and higher.