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Administrative data

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Description of key information

Due to lack of comparative quantitative data, absorption rates of 100% are indicated for all three routes. There are no concerns for bioaccumulation.

Key value for chemical safety assessment

Bioaccumulation potential:
low bioaccumulation potential
Absorption rate - oral (%):
100
Absorption rate - dermal (%):
100
Absorption rate - inhalation (%):
100

Additional information

C12-14 Alkyl polyethoxy glycidylether are formed after the reaction of C12-14 alcohol ethoxylate (2EO) with epichlorohydrin. The ratio of C12 to C14 alkyl chains is about 1:3.

There are no specific studies available that study absorption, distribution, metabolism or excretion of C12-14 Alkyl ethoxylated glycidylether. Due to lack of comparative quantitative data, absorption rates of 100% are indicated for all three routes. Profiling (see attached document) however indicates that oral absorption is likely to be high. As conservative approach, absorption via dermal route is also set at 100%, and an additional extrapolation factor of 2 from oral to inhalation route of exposure is taken into account for DNEL derivation.

 

The substance is not expected to be bio accumulative. No bio-accumulation study in fish or any other higher organism has been performed, but substance is readily biodegradable and has an estimated Kow of 3.5 based on solubility ratio of the substance separately in octanol and water (CMC value). After uptake, epoxides are hydrolised by epoxide hydrolases leading to diolsthat are readily further metabolized (glucuronidated and excreted). In repeated dose studies there is indication of liver induction suggested by increased liver weight at higher dose levels, indicative for a first pass metabolism after uptake.Thus, no bio-accumulation is expected. In addition, a BCF calculations (EpiSuite - BCFBAF Program v3.01) indicate a value between 26.1 and 116 L/kg wet-wt (for C12 resp. C14-Alkyl ethoxylated glycidylether) indicating a low bio-accumulation potential.