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Diss Factsheets
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EC number: 600-872-8 | CAS number: 108419-35-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 07 August 1985 to 11 August 1985
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
- Remarks:
- Analytical verification of the test item is not considered to be fully reliable.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 985
- Report date:
- 1985
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 203 (Fish, Acute Toxicity Test)
- Deviations:
- not applicable
- GLP compliance:
- yes
- Remarks:
- EPA Good Laboratory Practice Regulations set forth in 40 CFR Part 792
Test material
- Reference substance name:
- Acetic acid, C11-14-isoalkyl esters, C13-rich
- EC Number:
- 283-740-9
- EC Name:
- Acetic acid, C11-14-isoalkyl esters, C13-rich
- Cas Number:
- 84712-50-5
- Molecular formula:
- C15H30O2
- IUPAC Name:
- Acetic acid, C11-14-isoalkyl esters, C13-rich
Constituent 1
- Specific details on test material used for the study:
- SOURCE OF TEST MATERIAL
- Source and lot/batch No.of test material: Batch I
STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage condition of test material: Room temperature
- Stability under test conditions: The stability, identity, strength, and composition or other characteristics which appropriately identify the test substance are the responsibility of the Sponsor.
FORM AS APPLIED IN THE TEST (if different from that of starting material): Water soluble fraction of MRD-84-521
Sampling and analysis
- Analytical monitoring:
- yes
- Details on sampling:
- - Concentrations: The BW2 (The dilution water used during studies in the Environmental Toxicology Laboratory is a blend of reverse osmosis (RO) water and carbon filtered well water. For this study the ratio was approximately 1.8:1 RO to well water (BW2)) used for stock solution preparation and 100% stock solutions were sampled during the study.
- Sampling method: The aqueous samples received from the Environmental Toxicology Department were analyzed for Total Carbon (TC) by direct injection into the Dohrmann DC-80 Total Carbon Analyzer. At least two injections were made of each sample and only the mean value is reported.
Test solutions
- Vehicle:
- no
- Details on test solutions:
- PREPARATION AND APPLICATION OF TEST SOLUTION (especially for difficult test substances)
- Method: The water soluble fraction of MRD-84-521 was prepared by combining the test material and BW2 at a ratio of approximately 1:150. The mixture was then stirred slowly for approximately 72 hours. After the mixing period, the WSF was drawn off by means of a sampling tube. The MRD-84-521 test material water soluble fraction
was administered in aqueous solution via a diluter system. The test chambers were replicate 15 liter tanks containing approximately 14 liters of test solution.
Test organisms
- Test organisms (species):
- Pimephales promelas
- Details on test organisms:
- TEST ORGANISM
- Common name: Fathead Minnow
- Strain: Lot 41
- Source: Cultured in the Environmental Laboratory
- Age at study initiation (mean and range, SD): Approximately 25 weeks
- Length at study initiation (length definition, mean, range and SD): Mean length: 2.5 cm, SD 0.3
- Weight at study initiation (mean and range, SD): Mean weight: 0.276 g, SD 0.10
ACCLIMATION
- Acclimation period: at least 14 days prior to study
- Acclimation conditions (same as test or not): similar (Fish are kept in holding tanks with dilution water (BW2) similar in characteristics to that which was used during the test phase; fish were held in flow-through conditions prior to the test.)
- Type and amount of food during acclimation: Fish were fed ad libitum during normal holding, Rangen Salmon Starter and brine shrimp (Artemia salina)
- Health during acclimation (any mortality observed): none
FEEDING DURING TEST
- Food type: Fish were not fed during the study
Study design
- Test type:
- flow-through
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 96 h
Test conditions
- Hardness:
- 158 mg CaCO3 /L
- Test temperature:
- Mean: 21.78 +/- 0.26°C
Range: 21.0 - 22.0 °C - pH:
- Range: 7.6 - 8.0
- Dissolved oxygen:
- Range: 7.7 - 8.6 mg/L
- Nominal and measured concentrations:
- Nominal: Control, 6.25, 12.5, 25.0, 50.0, 100.0 % WSF
Measured: The Total Carbon analyses for the stock solution batches used during this study indicated that the test material water soluble fraction could not be measured in solution. The difference in Total Carbon between the BW2 and 100% stock falls into the realm of analytical variation for that method. As a result, the treatments were run nominally and no further concentration analysis was performed. - Details on test conditions:
- TEST SYSTEM
- Test vessel: tanks
- Material, size, headspace, fill volume: size: 15 L, fill volume: 14 L
- Renewal rate of test solution (frequency/flow rate): Dwell time: 40 min; total cycle time: 3 min 6 seconds
- No. of organisms per vessel: 10
- No. of vessels per concentration (replicates): 2 replicates
- No. of vessels per control (replicates): 2 replicates
- Biomass loading rate: approximately 0.023g fish/liter/24 hours
TEST MEDIUM / WATER PARAMETERS
- Culture medium different from test medium: no
- Intervals of water quality measurement: semi-annually
OTHER TEST CONDITIONS
- Adjustment of pH:
- Photoperiod: 16 hours light, 8 hours dark
- Light intensity: Mean daylight intensity ranged from 82 to 87 footcandles.
EFFECT PARAMETERS MEASURED (with observation intervals if applicable) : start of the test: 08:45; 24 h: 08.40, 13:00; 48 h: 09:00, 13:30; 72 h: 09:00, 13:00; 96 h: 13:00 (time)
TEST CONCENTRATIONS
- Range finding study: no - Reference substance (positive control):
- no
Results and discussion
Effect concentrations
- Key result
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- >= 1 mg/L
- Nominal / measured:
- estimated
- Conc. based on:
- test mat. (dissolved fraction)
- Basis for effect:
- mortality (fish)
- Remarks on result:
- not measured/tested
- Details on results:
- - Behavioural abnormalities: There were no behavioral or coloration abnormalities noted during this study.
- Observations on body length and weight: Control fish were individually weighed and measured in accordance to guidelines developed to insure consistency. Data were recorded on the appropriate form in the study data book (not included in study report).
- Mortality of control: None
- Abnormal responses: None
- Effect concentrations exceeding solubility of substance in test medium: The Total Carbon analyses for the stock solution batches used during this study indicated that the test material water soluble fraction could not be measured in solution.
Due to a technician error, the computer water quality study was not started prior to study initiation. As a result, that information was extracted from the daily computer reports, exact copies of which are included in the raw data book. No study related data were lost. A number of temperature alarms occurred during which the temperature exceeded protocol specifications. The mean temperature during the study is within protocol specifications and the excursions appear insignificant to the outcome of the study.
Applicant's summary and conclusion
- Validity criteria fulfilled:
- not specified
- Remarks:
- Test method was not given and therefore validity was not evaluated, however survival in the control was 100%.
- Conclusions:
- Based on the estimated LC50 >1 mg/L, the test material is considered as acutely toxic to fish according to Regulation (EC) No. 1272/2008 (CLP).
- Executive summary:
There were no behavioural or colouration abnormalities noted during this study. There was no mortality observed during this study; as a result, no calculations were performed and no LC50 could be determined, but estimated. It was considered to be > 1 mg/L.
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