Registration Dossier
Registration Dossier
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EC number: 947-968-9 | CAS number: -
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 019
- Report date:
- 2019
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 436 (Acute Inhalation Toxicity: Acute Toxic Class Method)
- GLP compliance:
- yes
- Test type:
- fixed concentration procedure
- Limit test:
- yes
Test material
- Reference substance name:
- Product obtained by rectification during the manufacturing process of Dihydromyrcenol
- EC Number:
- 947-968-9
- Molecular formula:
- C10H18
- IUPAC Name:
- Product obtained by rectification during the manufacturing process of Dihydromyrcenol
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Food availability: Ad libitum
Drinking water: Tap water
Watering: Bottles
Quality control: Certificate of analysis will be included in the final report
Water availability: Ad libitum
Administration / exposure
- Route of administration:
- inhalation: aerosol
- Type of inhalation exposure:
- nose only
- Vehicle:
- air
- Details on inhalation exposure:
- Oxygen concentration in the exposure chamber will be at least 19% and carbon dioxide will not exceed 1%.
- Analytical verification of test atmosphere concentrations:
- yes
- Remarks:
- Gravimetric determination of the aerosol concentration
- Duration of exposure:
- ca. 4 h
- No. of animals per sex per dose:
- 6 animals for the first step (3 males and 3 females) and 2 spare animals. Each additional step will contain 3 males and 3 females.
- Control animals:
- yes
- Details on study design:
- - Observation period of at least 14 days
- Frequency of observations and weighing: No diet or drinking water will be available during exposure.
- Necropsy of survivors performed: yes/no
- Other examinations performed: clinical signs, body weight,organ weights, histopathology, other:
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- ca. 10 mg/L air (nominal)
- Based on:
- test mat.
- Exp. duration:
- 4 h
- Clinical signs:
- other:
Applicant's summary and conclusion
- Interpretation of results:
- Category 3 based on GHS criteria
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