Registration Dossier
Registration Dossier
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EC number: 206-406-6 | CAS number: 335-99-9
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
Data source
Reference
- Reference Type:
- publication
- Title:
- Beitrag zur Toxizität ω-H-polyfuorierter Carbonsäuren und einiger Alkohole gleicher C-Zahl
- Author:
- Schmidt P
- Year:
- 1 980
- Bibliographic source:
- Zeitschrift für die gesamte Hygiene und ihre Grenzgebiete 26, 9-13, 1980
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- LD50 for intraperitoneal application
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 2,2,3,3,4,4,5,5,6,6,7,7-dodecafluoroheptan-1-ol
- EC Number:
- 206-406-6
- EC Name:
- 2,2,3,3,4,4,5,5,6,6,7,7-dodecafluoroheptan-1-ol
- Cas Number:
- 335-99-9
- Molecular formula:
- C7H4F12O
- IUPAC Name:
- 2,2,3,3,4,4,5,5,6,6,7,7-dodecafluoroheptan-1-ol
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- on-site breeder (Zam:Wistar-C)
pelleted standard feed Sorte R (VEB, Versuchstierproduktion) and water ad libitum
weight at study initiation: 150-180 g
Temperature: 20 ± 2 °C
Humidity: 57-59 %
Acclimation period: > 1 week
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- other: 1,2-propane diol
- Details on exposure:
- VEHICLE
- Concentration in vehicle: 50 mg/mL - Doses:
- no data
- No. of animals per sex per dose:
- no data
- Details on study design:
- Duration of observation period following administration: 14 days
- Frequency of observations: daily
- Necropsy of perished and surviving animals performed: yes - Statistics:
- Statistics
LD50 was calculated with a computing system on the basis of Finneys probit analysis (1971).
Results and discussion
Any other information on results incl. tables
LD50 intraperitoneal: 225 mg/kg bw (175 -293 mg/kg bw)
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
