2,2,3,3,4,4,5,5,6,6,7,7-dodecafluoroheptan-1-ol

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

data from handbook or collection of data

Data source

Reference

Reference Type:

publication

Title:

Beitrag zur Toxizität ω-H-polyfuorierter Carbonsäuren und einiger Alkohole gleicher C-Zahl

Author:

Schmidt P

Year:

1980

Bibliographic source:

Zeitschrift für die gesamte Hygiene und ihre Grenzgebiete 26, 9-13, 1980

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 401 (Acute Oral Toxicity)

GLP compliance:

not specified

Test type:

standard acute method

Test material

Test material information

Constituent 1

Reference substance name:

2,2,3,3,4,4,5,5,6,6,7,7-dodecafluoroheptan-1-ol

EC Number:

206-406-6

EC Name:

2,2,3,3,4,4,5,5,6,6,7,7-dodecafluoroheptan-1-ol

Cas Number:

335-99-9

Molecular formula:

C7H4F12O

IUPAC Name:

2,2,3,3,4,4,5,5,6,6,7,7-dodecafluoroheptan-1-ol

Specific details on test material used for the study:

ω-H-Dodekafluorheptanol-1, MW 332.1

Test animals

Species:

rat

Strain:

Wistar

Sex:

male/female

Details on test animals or test system and environmental conditions:

on-site breeder (Zam:Wistar-C)
pelleted standard feed Sorte R (VEB, Versuchstierproduktion) and water ad libitum
weight at study initiation: 150-180 g
Temperature: 20 ± 2 °C
Humidity: 57-59 %
Acclimation period: > 1 week

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

other: 1,2-propane diol

Details on oral exposure:

VEHICLE
- Concentration in vehicle: 400 mg/mL

Doses:

no data

No. of animals per sex per dose:

no data

Details on study design:

- Duration of observation period following administration: 14 days
- Frequency of observations: daily
- Necropsy of perished and surviving animals performed: yes

Statistics:

LD50 was calculated with a computing system on the basis of Finneys probit analysis (1971).

Results and discussion

Effect levels

Effect levels 1

Sex:

male

Dose descriptor:

LD50

Effect level:

2 390 mg/kg bw

Based on:

test mat.

Remarks on result:

other: 2110 to 2720 mg/kg bw

Effect levels 2

Sex:

female

Dose descriptor:

LD50

Effect level:

3 010 mg/kg bw

Based on:

test mat.

Remarks on result:

other: 1620-3460 mg/kg bw

Applicant's summary and conclusion

Interpretation of results:

GHS criteria not met

Executive summary:

The acute oral toxicity was determined in a study on male and female Wistar rats. The test item was solved in 1,2 -propane diol (400 mg/mL) and administered once via oral gavage. The animals were observed for 14 days after treatment. LD50 values of 2390 mg/kg bw (2110 -2720 mg/kg bw) and 3010 mg/kg bw (2620 -3460 mg/kg bw) were recorded for males and females, respectively.