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Diss Factsheets

Ecotoxicological information

Long-term toxicity to aquatic invertebrates

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Administrative data

Link to relevant study record(s)

Description of key information

The significant reduction of the reproductive output at the concentration levels of 33.9 and 69.3 mg/L was the most sensitive effect in this study. 
Based on the significant reduction of the reproductive output at the concentration levels of 33.9 and 69.3 mg/L, the No Observed Effect Concentration (NOEC) after 21 days was assessed at 16.6 mg/L and the Lowest Observed Effect Concentration (LOEC) was assessed at 33.9 mg/L.
An EC50-value for the reduction of the reproductive output could not be calculated, because the reduction was limited to a maximum of 21 % within the tested concentration range. The EC10-value for the reduction of the reproductive output was calculated to be
9.98 mg/L.
Endpoints assessed Test item
Geometric mean measured test item concentration
[mg/L]
EC10 Reproduction
(with 95 % confidence limits) 9.98 mg/L (Not applicable)
NOECReproduction 16.6 mg/L
LOECReproduction 33.9 mg/L

Key value for chemical safety assessment

Fresh water invertebrates

Fresh water invertebrates
Effect concentration:
16.6 mg/L

Additional information

The significant reduction of the reproductive output at the concentration levels of 33.9 and 69.3 mg/L was the most sensitive effect in this study.

Based on the significant reduction of the reproductive output at the concentration levels of 33.9 and 69.3 mg/L, the No Observed Effect Concentration (NOEC) after 21 days was assessed at 16.6 mg/L and the Lowest Observed Effect Concentration (LOEC) was assessed at 33.9 mg/L.

An EC50-value for the reduction of the reproductive output could not be calculated, because the reduction was limited to a maximum of 21 % within the tested concentration range. The EC10-value for the reduction of the reproductive output was calculated to be

9.98 mg/L.

Endpoints assessed Test item

Geometric mean measured test item concentration

[mg/L]

EC10 Reproduction

(with 95 % confidence limits) 9.98 mg/L (Not applicable)

NOECReproduction 16.6 mg/L

LOECReproduction 33.9 mg/L