Registration Dossier
Registration Dossier
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EC number: 206-077-9 | CAS number: 299-35-4
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1976 - no further detail available
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: scientifically acceptable
Cross-referenceopen allclose all
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 976
- Report date:
- 1976
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Deviations:
- not applicable
- Principles of method if other than guideline:
- no further information
- GLP compliance:
- no
- Test type:
- acute toxic class method
- Limit test:
- no
Test material
- Reference substance name:
- 3-(4-amino-2-methylpyrimidin-5-ylmethyl)-5-(2-hydroxyethyl)-4-methylthiazole-2(3H)-thione
- EC Number:
- 206-077-9
- EC Name:
- 3-(4-amino-2-methylpyrimidin-5-ylmethyl)-5-(2-hydroxyethyl)-4-methylthiazole-2(3H)-thione
- Cas Number:
- 299-35-4
- Molecular formula:
- C12H16N4OS2
- IUPAC Name:
- 3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-5-(2-hydroxyethyl)-4-methyl-2,3-dihydro-1,3-thiazole-2-thione
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Doses:
- no data
- No. of animals per sex per dose:
- 10 animals per dose
- Control animals:
- not specified
Results and discussion
Effect levelsopen allclose all
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 14 800 mg/kg bw
- Remarks on result:
- other: after 10 days
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 16 000 mg/kg bw
- Remarks on result:
- other: after 24 h
- Sex:
- not specified
- Dose descriptor:
- other: LD 10
- Effect level:
- ca. 9 900 mg/kg bw
- Remarks on result:
- other: after 10 days
- Sex:
- not specified
- Dose descriptor:
- other: LD10
- Effect level:
- > 16 000 mg/kg bw
- Remarks on result:
- other: after 24 h
- Sex:
- not specified
- Dose descriptor:
- other: LD 90
- Effect level:
- > 16 000 mg/kg bw
- Remarks on result:
- other: after 10 days
Any other information on results incl. tables
no additional remarks
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Thiotiamin can not be classified as toxic under the described test conditions
- Executive summary:
The tests were carried out by using 10 animals per dosage group. The routes of adninistration were oral (by gavage). The lethal doses were determined by the computer method developed by Dr S. Wolf. The LD 10, LD 50, and LD 90 are stated for observation periods of 24 hours and of 10 days. The LD 50 value for Thiotiamin was found to be 14800 mg/kg bw (after 10 days).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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