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EC number: 946-188-6 | CAS number: -
In a combined repeated dose toxicity study with reproduction/developmental toxicity screening test in rats via the oral route, conducted according to current OECD guideline 422 and in compliance with GLP, no changes attributable to treatment were noted in offspring. There was no effect of maternal treatment on the number of implantations, post-implantation loss and live birth index, sex ratio, and subsequent offspring survival to day 13 of age at dosages of 100, 300 or 1000 mg/kg bw/day. There was also no effect of treatment with the test substance on offspring growth and development, indicated by clinical signs, offspring body weight or body weight gain, visible nipple count in male offspring on day 13 post partum, or ano-genital distance at 100, 300 or 1000 mg/kg bw/day. The NOEL was 1000 mg/kg bw/day.
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