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EC number: 946-188-6 | CAS number: -
Results after treatment for 6 hours with Reaction mass of Cucurbituril, Cucurbituril and Cucurbituriland the controls:
Ab-sorbanceWell 1(Tissue 1/2)
Ab-sorbanceWell 2 (Tissue 1/2)
Mean Absor-bance (Tissue 1/2)
Mean Absorbance* Tissue 1 and 2 minus
Mean Absorbance of2 Tissues*
Rel. Absorbance [%]Tissue 1 and 2**
Absolute Value of the Difference of the Rel. Absorbances [%]Tissue 1 and 2
Mean Rel. Absorbance
This in vitro GLP study was performed to assess the eye irritation potential of the test item "Reaction mass of Cucurbituril, Cucurbituril and Cucurbituril" by means of the Human Cornea Model Test in accordance with OECD test guideline 492. Additional tests with viable or freeze-killed tissues were not performed, since the test item was not coloured intensively, did not dye water or isopropanol, and did not reduce MTT..
About 50 mg of the test item or 50 µL of the controls, respectively, were applied to each of duplicate EpiOcular™tissue for 6 hours. Treatment with the positive control induced a decrease in the mean relative absorbance compared with the negative control to 31.8%, thus the validity of the test system is ensured. The acceptance criteria were met. The viability of tissue treated with the test item was 89.6 %. Since the viability of tissues treated with the test item did not decrease below 60%, the test item is not considered to possess an eye irritating potential.
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