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EC number: 946-188-6 | CAS number: -
Acute Oral Toxicity: LD50 >5000 mg/kg bw female Wistar rats (read-across from analogue substance).
The objective of the study was to assess the toxicity of test item CUCURBITURIL when administered as a single oral gavage dose to rats. The results of the study allow the test item to be ranked according to most classification systems currently used. Study performed in accordance with the study plan, OECD 423 (17th December 2001), Commission Regulation (EC) NO 440/2008 of 30 May 2008, B.1.Tris, EPA Health Effects Test Guidelines (OCSPP 8770.1100), United States, EPA 712-C-98-190 (1998) and the Principles of Good Laboratory Practice (Hungarian GLP Regulations: 42/2014. (VIII. 19.) EMMI decree of the Ministry of Human Capacities which corresponds to the OECD GLD, ENV/MC.CHEM (98)17).
Under the conditions of this study, the acute oral LD50 value of the test item CUCURBITURIL was found to be above 5000 mg/kg bw in female CRL: (WI) rats. According to the GHS criteria, CUCURBITURIL can be ranked as “Unclassified” for acute oral exposure.
The single-dose oral toxicity of Cucurbituril hydrochloride hydrate was performed according to the acute toxic class method in CRL: (WI) rats. Initially, one female was treated at a dose level of 5000 mg/kg bw by gavage after an overnight food withdrawal. Food was made available again 3 hours after the treatment. The test item was administered formulated in Methyl cellulose 1% at a concentration of 500 mg/mL at a dosing volume of 10 mL/kg bw. The test item did not cause mortality and two further animals were treated at the same dose level. Clinical observations were performed at 30 minutes, 1, 2, 3, 4 and 6 hours after dosing and daily for 14 days thereafter. Body weight was measured on Days -1, 0 and 7 and Day 14 before necropsy. All animals were subjected to a necropsy and a macroscopic examination.
The test substance did not cause mortality in these animals, and did not cause any test substance related effects on the animals. There were no changes in body weight gains or any macroscopic findings. Therefore, no further testing was required according to OECD 423 and Commission Regulation (EC) NO 440/2008 of 30 May 2008, B.1.Tris. Under the conditions of this study, the acute oral LD50 value of Cucurbituril hydrochloride hydrate was found to be above 5000 mg/kg bw in female CRL: (WI) rats.
Based on the available data, the test substance does not require classification for acute oral toxicity according to the CLP Regulation (EC) No 1272/2008.
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