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Environmental fate & pathways

Hydrolysis

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Reference
Endpoint:
hydrolysis
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 111 (Hydrolysis as a Function of pH)
Version / remarks:
2004
Deviations:
no
GLP compliance:
yes
Radiolabelling:
no
Analytical monitoring:
yes
Duration:
28 d
pH:
4
Temp.:
15 °C
Initial conc. measured:
50 mg/L
Duration:
28 d
pH:
7
Temp.:
50 °C
Initial conc. measured:
50 mg/L
Duration:
28 d
pH:
9
Temp.:
70 °C
Initial conc. measured:
50 mg/L
Transformation products:
yes
No.:
#1
% Recovery:
ca. 11
pH:
9
Temp.:
70 °C
Duration:
30 d
% Recovery:
ca. 27
pH:
9
Temp.:
50 °C
Duration:
30 d
% Recovery:
ca. 19
pH:
9
Temp.:
15 °C
Duration:
30 d
% Recovery:
ca. 45
pH:
7
Temp.:
70 °C
Duration:
30 d
% Recovery:
ca. 40
pH:
7
Temp.:
50 °C
Duration:
30 d
% Recovery:
ca. 2
pH:
7
Temp.:
15 °C
Duration:
28 d
% Recovery:
ca. 7
pH:
4
Temp.:
70 °C
Duration:
30 d
% Recovery:
ca. 7
pH:
4
Temp.:
50 °C
Duration:
30 d
% Recovery:
ca. 7
pH:
4
Temp.:
15 °C
Duration:
8 d
Key result
pH:
4
Temp.:
15 °C
DT50:
3.1 d
Type:
(pseudo-)first order (= half-life)
Key result
pH:
4
Temp.:
50 °C
DT50:
3.8 d
Type:
(pseudo-)first order (= half-life)
Key result
pH:
4
Temp.:
70 °C
DT50:
2.8 d
Type:
(pseudo-)first order (= half-life)
Key result
pH:
7
Temp.:
15 °C
DT50:
1.4 d
Type:
second order
Key result
pH:
7
Temp.:
50 °C
DT50:
11.1 d
Type:
second order
Key result
pH:
7
Temp.:
70 °C
DT50:
10 d
Type:
second order
Key result
pH:
9
Temp.:
15 °C
DT50:
11.4 d
Type:
(pseudo-)first order (= half-life)
Key result
pH:
9
Temp.:
50 °C
DT50:
11.7 d
Type:
(pseudo-)first order (= half-life)
Key result
pH:
9
Temp.:
70 °C
DT50:
7.3 d
Type:
(pseudo-)first order (= half-life)
Validity criteria fulfilled:
yes
Conclusions:
The substance is susceptible to hydrolysis under environmental conditions (pH 4 -9). Hydrolysis is more rapid in neutral and acidic conditions
Executive summary:

A GLP study was conducted in accordance with OECD test guideline 111 using non-radiolabelled test material. The definitive test was conducted at 15, 50 and 70 °C at pH values of 4, 7 and 9. The hydrolysis of the substance was pH dependent. At pH 4 and pH 9 a first order reaction was found; the reaction at pH 7 was second order. The hydrolysis reaction was much more related to the pH than to the temperature.

Description of key information

The substance is susceptible to hydrolysis under environmental conditions (pH 4 -9). Hydrolysis is more rapid in neutral and acidic conditions.

Key value for chemical safety assessment

Half-life for hydrolysis:
1.4 d
at the temperature of:
15 °C

Additional information

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