1-[([[(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl]oxy]carbonyl)oxy]pyrrolidine-2,5-dione

Melting point / freezing point

Link to relevant study record(s)

Reference

Endpoint:

melting point/freezing point

Type of information:

experimental study

Adequacy of study:

key study

Study period:

2017-11-22 to 2018-08-16

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

OECD Guideline 102 (Melting point / Melting Range)

Deviations:

no

Qualifier:

according to guideline

Guideline:

EU Method A.1 (Melting / Freezing Temperature)

Deviations:

no

Qualifier:

according to guideline

Guideline:

EPA OPPTS 830.7200 (Melting Point / Melting Range)

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Type of method:

differential scanning calorimetry

Specific details on test material used for the study:

- Batch n°: I16FD3167
- Analytical purity: 98.2%
- Expiration date: 26 October 2018 (retest date)
- Storage condition: In refrigerator (2-8°C)

Key result

Melting / freezing pt.:

ca. 137.9 °C

Atm. press.:

1 013.25 hPa

Decomp. temp.:

> 250 °C

Remarks on result:

other: A black and dark brown molten residue remained after the preliminary and first main test, indicating reaction and/or decomposition.

Preliminary test

From the TGA curve it could be derived that the weight of the sample decreased significantly from 275°C. At 295°C the sample weight has decreased by 25%. After the experiment, a black molten residue remained in the sample container (original colour: white). The change of the colour indicated reaction and/or decomposition of the test item.

Main tests

In order to determine the melting more precisely, the DSC curve with a heating rate of 20°C/min was obtained and showed an endothermic peak between 100°C and 150°C followed by an exothermic effect starting at 250°C. The extrapolated onset temperature of the peak was 138.011°C. The endothermic effect was most likely obtained due to melting, while the exothermic effect was probably obtained due to reaction and/or decomposition of the test item. After the experiment, a dark brown molten residue remained.

To investigate the melting peak between 100°C and 150°C, a repeated heating cycle was applied and stopped after the melting peak (at 160°C). The extrapolated onset temperature of the melting peak was 137.831°C. After the experiment, a colourless molten residue remained in the sample container.

The melting temperature of T002632 was determined as the average melting temperature obtained from Experiment 1 and Experiment 2 and equals 137.9°C (411.1K).

Conclusions:

The melting temperature of the substance was determined at 137.9°C (411.1K) by using DSC.

Description of key information

Based on a GLP study according to OECD guideline 102, EU Method A.1 and EPA OPPTS 830.7200 (K1, Reingruber, 2019), the melting point was determined to be 137.9°C by ussing differential scanning calorimetry.

Key value for chemical safety assessment

Melting / freezing point at 101 325 Pa:

137.9 °C