Registration Dossier

Administrative data

Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
01/11/17 - 26/04/18
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2018
Report Date:
2018

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
OECD Guideline 105 (Water Solubility)
Deviations:
no
GLP compliance:
yes (incl. certificate)
Type of method:
column elution method

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
gas
Specific details on test material used for the study:
Identity:HCFO-1224yd(Z)
Chemical name:(Z)-1-chloro-2,3,3,3-tetrafluoropropene
Physical state:Gas
Storage conditions:Ambient
Lot number:170403
Purity:99.4%
Expiry date:03 June 2018
Date received:13 June 2017

Results and discussion

Water solubility
Water solubility:
ca. 540 mg/L
Temp.:
20 °C
pH:
>= 6.9 - <= 7.9

Any other information on results incl. tables

The detector calibration was found to be linear over the range investigated with a regression coefficient of 0.9993 (Table 1).

Table 2 presents a summary of the results of the test. It shows a measured solubility of  539 ± 69 mg/L, while Table 3 presents the primary data for the test.  

An acceptable mean recovery of approximately 120% of HCFO-1224yd(Z) from fortified samples was achieved. Table 4 shows the recovery data.

Table 1: Standard calibration for HCFO-1224yd(Z)

Standard concentration (mg/L) Peak area   108.5 435.84 86.80 337.29 65.10 254.67 43.40 169.93 21.70 69.561 10.85 29.823 5.425 14.587  

 Standard concentration (mg/L)  Peak area
 108.5  435.84
 86.80 337.29
 65.10  254.67
 43.40 169.93 
 21.70 69.561 
 10.85 29.823 
 5.425 14.587 

Linear regression: y = 4.05x - 9.22                   (including x = 0, y = 0) r = 0.9993

x = concentration y = peak area

Table 2: Measurement of Water Solubility at 20 °C

 Sample Number Time (hours)  Concentration (mg/L) Mean Concentration (mg/L)  pH 
 1A, 1B  1  248,300    
 2A, 2B  2  311,289    
 3A, 3B  3  317,295    
 4A, 4B  4      
 5A, 5B  5      
 6A, 6B  6      
 7A, 7B  7      
 8A, 8B  8      
 9A, 9B  9      

Applicant's summary and conclusion

Conclusions:
The water solubility of HCFO-1224yd(Z) was determined to be 540 mg/L at 20°C.
Executive summary:

The water solubility of HCFO-1224yd(Z) was determined to be 540 mg/L at 20 °C.