Registration Dossier
Registration Dossier
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EC number: 217-100-7 | CAS number: 1739-83-9
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 019
- Report date:
- 2019
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- acute toxic class method
Test material
- Reference substance name:
- 1,2,4,5-tetramethyl-1H-imidazole
- EC Number:
- 217-100-7
- EC Name:
- 1,2,4,5-tetramethyl-1H-imidazole
- Cas Number:
- 1739-83-9
- Molecular formula:
- C7H12N2
- IUPAC Name:
- tetramethyl-1H-imidazole
Constituent 1
Results and discussion
Effect levels
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- >= 2 000 mg/kg bw
Any other information on results incl. tables
Under the test conditions, the test item1,2,4,5-tetramethyl-1H-imidazole,when administered by oral route in female rats, cause deaths, for every step taken at the dose levels of2000mg.Kg-1ofbody weight.In clinical examinations, the tested animals showsystemic signs of toxicity. In macroscopic evaluations noalterations were observed during the necropsies.Based on the flow chart with the starting dose of 2000 mg.Kg-1ofbody weight, the test item was classified as category 4 (>300-2000), according to the GHS (Globally Harmonized Classification System for Chemical Substances and Mixtures).The oral LD50value of test item1,2,4,5-tetramethyl-1H-imidazole,for female rats, was estimated in500 mg.Kg-1of body weight.
Applicant's summary and conclusion
- Interpretation of results:
- Category 4 based on GHS criteria
- Conclusions:
- >2000 mg.Kg-1
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