Registration Dossier

Diss Factsheets

Administrative data

Endpoint:
skin irritation / corrosion, other
Remarks:
aaa
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2019.04.05~2019.05.21
Reliability:
1 (reliable without restriction)

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2019
Report date:
2019

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
Version / remarks:
Adopted : 28 July 2015
GLP compliance:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
Trimethyloctylammonium methyl sulphate
EC Number:
265-332-2
EC Name:
Trimethyloctylammonium methyl sulphate
Cas Number:
65059-42-9
Molecular formula:
C11H26N.CH3O4S
IUPAC Name:
trimethyl(octyl)azanium methyl sulfate
Test material form:
solid: bulk

Test animals

Species:
rabbit
Strain:
New Zealand White
Remarks:
Yac:NZW(KBL), Rabbit, SPF

Test system

Observation period:
72h
Number of animals:
3 males (Initial test : 1 head, Confirmatory test : 2 head)

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
erythema score
Basis:
animal #1
Time point:
24/48/72 h
Score:
> 0 - <= 1
Max. score:
1
Remarks on result:
probability of weak irritation
Irritation parameter:
edema score
Basis:
animal #2
Time point:
24/48/72 h
Score:
> 0 - <= 1
Max. score:
1
Remarks on result:
probability of weak irritation

Applicant's summary and conclusion

Interpretation of results:
study cannot be used for classification
Conclusions:
As a result of acute dermal irritation and corrosion test in rabbit, Trimethyloctylammonium
methyl sulphate was caused weak skin reactions but was not considered to be
classified as Hazard Class according to Globally Harmonized System of Classification
and Labelling of Chemicals (GHS).

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