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EC number: 427-900-1 | CAS number: 198404-98-7
The primary skin irritation potential of the test article was investigated by a topical application of 0.5 ml to 6cm2 intact dorsal skin of each of three young adult New Zealand White rabbits. The duration of the treatment was 4 hours.The scoring of skin reactions was performed 1, 24, 48 and 72 hours as well as 7 and 14 days after removal of the dressing. The scores of each animal at the following reading times (24, 48 and 72 hours) were used in calculating the respective mean values for each type of lesion.
The primary irritation score was calculated by totalling the individual cumulative scores at 24, 48 and 72 hours and then dividing by the number of data points. The primary eye irritation score was 1.78 (max 8.0). Local signs (mean values from 24 to 72 hours) consisted of grade 0.89 erythema and grade 0.89 edema.
Very slight reddening and swelling were noted in two animals after 24 hours and in all animals from 48 hours to 7 days after application. All findings were reversible after 14 days.
The test article did not cause staining of the treated skin.
No corrosive effects were noted on the treated skin of any animal at any measuring interval.
Based upon the referred classification criteria (EEC comission directive 93/21/EEC of April 27, 1993), the test article is considered to be 'not irritating' to rabbit skin.
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