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EC number: 427-900-1 | CAS number: 198404-98-7
A group of five male and five female HanIbm: WIST (SPF) rats was treated with Javanol at 2000 mg/kg by oral gavage. The test article was suspended in vehicle polyethylene glycol (PEG400) at a concentration of 0.2 g/ml and administered at a volume of 10 ml/kg. The animals were examined for clinical signs four times during day 1 once daily during days 2 -15. Mortality/viability were recorded together with clinical signs at the same time intervals. Body weights were recorded on day 1 prior to administration and on days 8 and 15. All animals were necropsied and examined macroscopically.
No deaths occured during the study.
No clinical signs of toxicity were observed during the observation period.
The body weight of the animals was within the range of physiological variability known for rats of this strain and age.
No macroscopic findings were observed at necropsy.
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