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Ecotoxicological information

Long-term toxicity to aquatic invertebrates

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Reference
Endpoint:
long-term toxicity to aquatic invertebrates
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
guideline study without detailed documentation
Justification for type of information:
Experimental study made available by ECHA
Qualifier:
according to
Guideline:
other: Directive 92/69/CE, C.2
Principles of method if other than guideline:
The long term toxicity of test chemical was studied on the reproduction of Dapnia magna.
GLP compliance:
yes
Specific details on test material used for the study:
Identity and concentration of solvent for dispersal: Acetone (used as a pre-solvent)
0.01%
Analytical monitoring:
not specified
Details on sampling:
not specified
Vehicle:
not specified
Details on test solutions:
not specified
Test organisms (species):
Daphnia magna
Details on test organisms:
not specified
Test type:
not specified
Water media type:
freshwater
Total exposure duration:
48 h
Remarks on exposure duration:
not specified
Post exposure observation period:
not specified
Hardness:
250 mg CaCO3/L
Test temperature:
not specified
pH:
not specified
Dissolved oxygen:
not specified
Salinity:
not specified
Conductivity:
not specified
Nominal and measured concentrations:
not specified
Details on test conditions:
not specified
Reference substance (positive control):
not specified
Duration:
24 h
Dose descriptor:
EC50
Effect conc.:
0.69 mg/L
Conc. based on:
test mat.
Duration:
48 h
Dose descriptor:
EC50
Effect conc.:
0.38
Conc. based on:
test mat.
Duration:
48 h
Dose descriptor:
other: EC100
Effect conc.:
1.67 mg/L
Conc. based on:
test mat.
Duration:
48 h
Dose descriptor:
NOEC
Effect conc.:
0.15 mg/L
Conc. based on:
test mat.
Details on results:
%Concentration loss over test: 34 ... 67
Validity criteria fulfilled:
not specified
Conclusions:
The effect of the test chemical was studied on the reproduction of the fresh water flea daphnia magna, no effect EC50 value at 24 and 48 hours were considered to be 0.69 and 0.8 mg/l respectively and the EC100 value was considered to be 1.67 mg/l at 48 hours and the NOEC value was considered to be 0.15 mg/l at 48 hours.
Executive summary:

The study outlines the effect of test chemical on aquatic invertebrate freshwater daphnia magna. Test was performed as per the Directive 92/69/CE, C.2. The effect of the test chemical was studied on the reproduction of the fresh water flea daphnia magna, no effect EC50 value at 24 and 48 hours were considered to be 0.69 and 0.8 mg/l respectively and the EC100 value was considered to be 1.67 mg/l  at 48 hours and the NOEC value was considered to be 0.15 mg/l at 48 hours. Based on the LC50 value of the test chemical (1-METHYL-2-(1,2,2-TRIMETHYLBICYCLO(3.1.0)-HEX-3-YLMETHYL)CYCLOPROPYL)METHANOL( MIXTURE OF DIASTEREOISOMERS), it was concluded that the test chemical (1-METHYL-2-(1,2,2-TRIMETHYLBICYCLO(3.1.0)-HEX-3-YLMETHYL)CYCLOPROPYL)METHANOL( MIXTURE OF DIASTEREOISOMERS) was considered as toxic and can be consider to be classified as aquatic chronic 1 category as per CLP classification criteria.

Description of key information

The study outlines the effect of test chemical on aquatic invertebrate freshwater daphnia magna. Test was performed as per the Directive 92/69/CE, C.2. The effect of the test chemical was studied on the reproduction of the fresh water flea daphnia magna, no effect EC50 value at 24 and 48 hours were considered to be 0.69 and 0.8 mg/l respectively and the EC100 value was considered to be 1.67 mg/l  at 48 hours and the NOEC value was considered to be 0.15 mg/l at 48 hours. Based on the LC50 value of the test chemical (1-METHYL-2-(1,2,2-TRIMETHYLBICYCLO(3.1.0)-HEX-3-YLMETHYL)CYCLOPROPYL)METHANOL( MIXTURE OF DIASTEREOISOMERS), it was concluded that the test chemical (1-METHYL-2-(1,2,2-TRIMETHYLBICYCLO(3.1.0)-HEX-3-YLMETHYL)CYCLOPROPYL)METHANOL( MIXTURE OF DIASTEREOISOMERS) was considered as toxic and can be consider to be classified as aquatic chronic 1 category as per CLP classification criteria.

Key value for chemical safety assessment

EC10, LC10 or NOEC for freshwater invertebrates:
0.15 mg/L

Additional information

The study outlines the effect of test chemical on aquatic invertebrate freshwater daphnia magna. Test was performed as per the Directive 92/69/CE, C.2. The effect of the test chemical was studied on the reproduction of the fresh water flea daphnia magna, no effect EC50 value at 24 and 48 hours were considered to be 0.69 and 0.8 mg/l respectively and the EC100 value was considered to be 1.67 mg/l  at 48 hours and the NOEC value was considered to be 0.15 mg/l at 48 hours. Based on the LC50 value of the test chemical (1-METHYL-2-(1,2,2-TRIMETHYLBICYCLO(3.1.0)-HEX-3-YLMETHYL)CYCLOPROPYL)METHANOL( MIXTURE OF DIASTEREOISOMERS), it was concluded that the test chemical (1-METHYL-2-(1,2,2-TRIMETHYLBICYCLO(3.1.0)-HEX-3-YLMETHYL)CYCLOPROPYL)METHANOL( MIXTURE OF DIASTEREOISOMERS) was considered as toxic and can be consider to be classified as aquatic chronic 1 category as per CLP classification criteria.