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Short-term toxicity to aquatic invertebrates

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Reference
Endpoint:
short-term toxicity to aquatic invertebrates
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
guideline study without detailed documentation
Justification for type of information:
Experimental study made available by ECHA
Qualifier:
according to
Guideline:
other: 92/69/EEC, C2 OECD 202
Principles of method if other than guideline:
Short term toxicity study of test chemical (1-METHYL-2-(1,2,2-TRIMETHYLBICYCLO(3.1.0)-HEX-3-YLMETHYL)CYCLOPROPYL)METHANOL( MIXTURE OF DIASTEREOISOMERS) on aquatic crustacea Daphnia magna was carried for 48 hrs.
GLP compliance:
not specified
Specific details on test material used for the study:
- Name of test material (IUPAC name): (1-METHYL-2-(1,2,2-TRIMETHYLBICYCLO(3.1.0)-HEX-3-YLMETHYL)CYCLOPROPYL)METHANOL( MIXTURE OF DIASTEREOISOMERS)
- Common name: Lokanol
- Molecular formula: C15H26O
- Molecular weight: 222.3694 g/mol
- InChl: 1S/C15H26O/c1-13(2)10(6-12-8-15(12,13)4)5-11-7-14(11,3)9-16/h10-12,16H,5-9H2,1-4H3
- Substance type: Organic
Details on test solutions:
Identity and concentration of auxiliary solvent for dispersal: Acetone (used as a pre-solvent)
0.01 %
Test organisms (species):
Daphnia magna
Test type:
static
Water media type:
freshwater
Total exposure duration:
48 h
Hardness:
250 mg CaCO3/L
Duration:
24 h
Dose descriptor:
EC50
Effect conc.:
0.69 mg/L
Conc. based on:
test mat.
Basis for effect:
mobility
Duration:
48 h
Dose descriptor:
EC50
Effect conc.:
0.38 mg/L
Conc. based on:
test mat.
Basis for effect:
mobility
Duration:
48 h
Dose descriptor:
EC100
Effect conc.:
1.67 mg/L
Conc. based on:
test mat.
Basis for effect:
mobility
Duration:
48 h
Dose descriptor:
NOEC
Effect conc.:
0.15 mg/L
Conc. based on:
test mat.
Basis for effect:
mobility
Details on results:
%Concentration loss over test: 34 ... 67
Validity criteria fulfilled:
not specified
Conclusions:
The EC50 value obtained was 0.38 mg/l when the test chemical (1-METHYL-2-(1,2,2-TRIMETHYLBICYCLO(3.1.0)-HEX-3-YLMETHYL)CYCLOPROPYL)METHANOL( MIXTURE OF DIASTEREOISOMERS) exposed to daphnia magna for 48hrs.
Executive summary:

Determination of short term toxicity of test chemical (1-METHYL-2-(1,2,2-TRIMETHYLBICYCLO(3.1.0)-HEX-3-YLMETHYL)CYCLOPROPYL)METHANOL( MIXTURE OF DIASTEREOISOMERS) (CAS no. 198404-98-7) was studied on aquatic invertebrate daphnia magna for 48hrs. study was performed according to the other guideline 92/69/EEC, C2 OECD 202 by performing static system.After the exposure of chemical for 48hrs, toxicity was observed. Based on the immobilization of daphnia magna due to the test chemical at duration of 96 hours, the EC50 value was considered to be 0.38 mg/l and the NOEC value was considered to be 0.15 mg/l.Based on the EC50 value of test chemical (1-METHYL-2-(1,2,2-TRIMETHYLBICYCLO(3.1.0)-HEX-3-YLMETHYL)CYCLOPROPYL)METHANOL( MIXTURE OF DIASTEREOISOMERS), it was concluded that the test chemical (1-METHYL-2-(1,2,2-TRIMETHYLBICYCLO(3.1.0)-HEX-3-YLMETHYL)CYCLOPROPYL)METHANOL( MIXTURE OF DIASTEREOISOMERS) was consider as toxic and can be consider to be classified as aquatic chronic/acute 1 category as per CLP classification criteria.

Description of key information

Determination of short term toxicity of test chemical (1-METHYL-2-(1,2,2-TRIMETHYLBICYCLO(3.1.0)-HEX-3-YLMETHYL)CYCLOPROPYL)METHANOL( MIXTURE OF DIASTEREOISOMERS) (CAS no. 198404-98-7) was studied on aquatic invertebrate daphnia magna for 48hrs. study was performed according to the other guideline 92/69/EEC, C2 OECD 202 by performing static system.After the exposure of chemical for 48hrs, toxicity was observed. Based on the immobilization of daphnia magna due to the test chemical at duration of 96 hours, the EC50 value was considered to be 0.38 mg/l and the NOEC value was considered to be 0.15 mg/l.Based on the EC50 value of test chemical (1-METHYL-2-(1,2,2-TRIMETHYLBICYCLO(3.1.0)-HEX-3-YLMETHYL)CYCLOPROPYL)METHANOL( MIXTURE OF DIASTEREOISOMERS), it was concluded that the test chemical (1-METHYL-2-(1,2,2-TRIMETHYLBICYCLO(3.1.0)-HEX-3-YLMETHYL)CYCLOPROPYL)METHANOL( MIXTURE OF DIASTEREOISOMERS) was consider as toxic and can be consider to be classified as aquatic chronic /acute 1 category as per CLP classification criteria.

Key value for chemical safety assessment

EC50/LC50 for freshwater invertebrates:
0.38 mg/L

Additional information

Determination of short term toxicity of test chemical (1-METHYL-2-(1,2,2-TRIMETHYLBICYCLO(3.1.0)-HEX-3-YLMETHYL)CYCLOPROPYL)METHANOL( MIXTURE OF DIASTEREOISOMERS) (CAS no. 198404-98-7) was studied on aquatic invertebrate daphnia magna for 48hrs. study was performed according to the other guideline 92/69/EEC, C2 OECD 202 by performing static system.After the exposure of chemical for 48hrs, toxicity was observed. Based on the immobilization of daphnia magna due to the test chemical at duration of 96 hours, the EC50 value was considered to be 0.38 mg/l and the NOEC value was considered to be 0.15 mg/l.Based on the EC50 value of test chemical (1-METHYL-2-(1,2,2-TRIMETHYLBICYCLO(3.1.0)-HEX-3-YLMETHYL)CYCLOPROPYL)METHANOL( MIXTURE OF DIASTEREOISOMERS), it was concluded that the test chemical (1-METHYL-2-(1,2,2-TRIMETHYLBICYCLO(3.1.0)-HEX-3-YLMETHYL)CYCLOPROPYL)METHANOL( MIXTURE OF DIASTEREOISOMERS) was consider as toxic and can be consider to be classified as aquatic chronic/acute 1 category as per CLP classification criteria.