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Ecotoxicological information

Long-term toxicity to fish

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Reference
Endpoint:
long-term toxicity to fish, other
Remarks:
deactivated phrase
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
guideline study without detailed documentation
Justification for type of information:
Experimental study made available by ECHA
Qualifier:
according to
Guideline:
other: OECD Guidelines. No. 210
Principles of method if other than guideline:
To determine long term toxicity of test chemical (1-METHYL-2-(1,2,2-TRIMETHYLBICYCLO(3.1.0)-HEX-3-YLMETHYL)CYCLOPROPYL)METHANOL( MIXTURE OF DIASTEREOISOMERS) in fish
GLP compliance:
yes
Specific details on test material used for the study:
- Name of test material (IUPAC name): (1-METHYL-2-(1,2,2-TRIMETHYLBICYCLO(3.1.0)-HEX-3-YLMETHYL)CYCLOPROPYL)METHANOL( MIXTURE OF DIASTEREOISOMERS)
- Common name: Lokanol
- Molecular formula: C15H26O
- Molecular weight: 222.3694 g/mol
- InChl: 1S/C15H26O/c1-13(2)10(6-12-8-15(12,13)4)5-11-7-14(11,3)9-16/h10-12,16H,5-9H2,1-4H3
- Substance type: Organic
Analytical monitoring:
not specified
Details on sampling:
not specified
Vehicle:
not specified
Details on test solutions:
Identity and concentration of solvent for dispersal: Acetone (used as a pre-solvent)
0.01%
Test organisms (species):
other: fish
Details on test organisms:
no data
Test type:
flow-through
Water media type:
freshwater
Total exposure duration:
30 d
Remarks on exposure duration:
no data
Post exposure observation period:
no data
Hardness:
250 mg CaCO3/L
Test temperature:
no data
pH:
no data
Dissolved oxygen:
no data
Salinity:
no data
Conductivity:
no data
Nominal and measured concentrations:
no data
Details on test conditions:
no data
Reference substance (positive control):
not specified
Duration:
30 d
Dose descriptor:
LC50
Effect conc.:
0.14 mg/L
Conc. based on:
test mat.
Basis for effect:
mortality
Duration:
28 d
Dose descriptor:
NOEC
Effect conc.:
0.055 mg/L
Conc. based on:
test mat.
Basis for effect:
other: total(NOEC)
Duration:
28 d
Dose descriptor:
NOEC
Effect conc.:
0.055 mg/L
Conc. based on:
test mat.
Basis for effect:
length
Duration:
28 d
Dose descriptor:
NOEC
Effect conc.:
0.055 mg/L
Conc. based on:
test mat.
Basis for effect:
weight
Duration:
28 d
Dose descriptor:
NOEC
Effect conc.:
0.104 mg/L
Conc. based on:
test mat.
Basis for effect:
other: post hatch survival
Duration:
28 d
Dose descriptor:
NOEC
Effect conc.:
0.225 mg/L
Conc. based on:
test mat.
Basis for effect:
other: hatching time
Duration:
28 d
Dose descriptor:
NOEC
Effect conc.:
0.225 mg/L
Conc. based on:
test mat.
Basis for effect:
other: egg survival
Duration:
30 d
Dose descriptor:
LOEC
Effect conc.:
0.1 mg/L
Conc. based on:
test mat.
Validity criteria fulfilled:
not specified
Conclusions:
On the basis of no effects observed in fish, freshwater system, the LC50 value based on the mortality for 30 days was considered to be 0.14 mg/l and NOEC values based on other effects such as length,weight,post hatching time , hatching time and egg survival for 28 days was considered to be 0.55,0.55,0.104,0.225,0.225 mg/l respectively and the LOEC value for 30 days was considered to be 0.1 mg/l accordance to the OECD Guidelines. No. 210.
Executive summary:

Long term fish test was observed for the test substance in accordance to the OECD Guidelines. No. 210 , the test was conducted for 30 days in flow- through method.The effect on mortality , weight , length , post hatching time , hatching time and egg survival were observed.The LC50 value based on the mortality for 30 days was considered to be 0.14 mg/l and NOEC values based on other effects such as length,weight,post hatching time , hatching time and egg survival for 28 days was considered to be 0.55,0.55,0.104,0.225,0.225 mg/l respectively and the LOEC value for 30 days was considered to be 0.1 mg/l.

Based on the LC50 value of the test chemical (1-METHYL-2-(1,2,2-TRIMETHYLBICYCLO(3.1.0)-HEX-3-YLMETHYL)CYCLOPROPYL)METHANOL( MIXTURE OF DIASTEREOISOMERS), it was concluded that the test chemical (1-METHYL-2-(1,2,2-TRIMETHYLBICYCLO(3.1.0)-HEX-3-YLMETHYL)CYCLOPROPYL)METHANOL( MIXTURE OF DIASTEREOISOMERS) was considered as toxic and can be consider to be classified as aquatic chronic 1 category as per CLP classification criteria.

Description of key information

Long term fish test was observed for the test substance in accordance to the OECD Guidelines. No. 210 , the test was conducted for 30 days in flow- through method.The effect on mortality , weight , length , post hatching time , hatching time and egg survival were observed.The LC50 value based on the mortality for 30 days was considered to be 0.14 mg/l and NOEC values based on other effects such as length,weight,post hatching time , hatching time and egg survival for 28 days was considered to be 0.55,0.55,0.104,0.225,0.225 mg/l respectively and the LOEC value for 30 days was considered to be 0.1 mg/l.

Key value for chemical safety assessment

EC10, LC10 or NOEC for freshwater fish:
0.55 mg/L

Additional information

Long term fish test was observed for the test substance in accordance to the OECD Guidelines. No. 210 , the test was conducted for 30 days in flow- through method.The effect on mortality , weight , length , post hatching time , hatching time and egg survival were observed.The LC50 value based on the mortality for 30 days was considered to be 0.14 mg/l and NOEC values based on other effects such as length,weight,post hatching time , hatching time and egg survival for 28 days was considered to be 0.55,0.55,0.104,0.225,0.225 mg/l respectively and the LOEC value for 30 days was considered to be 0.1 mg/l.

Based on the LC50 value of the test chemical (1-METHYL-2-(1,2,2-TRIMETHYLBICYCLO(3.1.0)-HEX-3-YLMETHYL)CYCLOPROPYL)METHANOL( MIXTURE OF DIASTEREOISOMERS), it was concluded that the test chemical (1-METHYL-2-(1,2,2-TRIMETHYLBICYCLO(3.1.0)-HEX-3-YLMETHYL)CYCLOPROPYL)METHANOL( MIXTURE OF DIASTEREOISOMERS) was considered as toxic and can be consider to be classified as aquatic chronic 1 category as per CLP classification criteria.