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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2002
Report date:
2002

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
GLP compliance:
not specified
Test type:
standard acute method
Limit test:
yes

Test material

Constituent 1
Reference substance name:
Olive oil decyl esters
EC Number:
948-056-3
IUPAC Name:
Olive oil decyl esters
Constituent 2
Chemical structure
Reference substance name:
2,6,10,15,19,23-hexamethyltetracosane
EC Number:
203-825-6
EC Name:
2,6,10,15,19,23-hexamethyltetracosane
Cas Number:
111-01-3
Molecular formula:
C30H62
IUPAC Name:
2,6,10,15,19,23-hexamethyltetracosane
Test material form:
liquid

Test animals

Species:
rat
Strain:
not specified
Sex:
male/female

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
other: Squalane
Doses:
The rats were administered a single dose, oraly, by gavage of 2000mg/kg of body weight (of hydrogenated decyl olive oil esters at 10% in squalane).
Meaning the hydrogenated decyl olive oil esters dose was 200 mg/kg of body weight.
No. of animals per sex per dose:
5 males and 5 nulliparous and non-pregnant females
Control animals:
no

Results and discussion

Effect levels
Key result
Sex:
male/female
Dose descriptor:
LD50
Effect level:
>= 200 mg/kg bw
Mortality:
no mortality was observed during the 14 days of observation.
Clinical signs:
other: no clinical signs were observed during the 14 days of observation except for a slight piloerection on day 1 after treatment.
Gross pathology:
none observed

Applicant's summary and conclusion

Interpretation of results:
Category 3 based on GHS criteria
Executive summary:

The test substance at 10% in squalane had a LD50>2000mg/kg, meaning LD50>200mg/kg for pure substance.